ReviewJournal of critical care2017
Dysbiosis in the intensive care unit: Microbiome science coming to the bedside.
Review in Journal of critical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review.Systematic reviews · 2021Pooled it
- Effect of mixed probiotics on pulmonary flora in patients with mechanical ventilation: an exploratory randomized intervention study.European journal of medical research · 2024Trial
- Trial
- Spatio-temporal differences and associations between upper and lower respiratory microbiota in ventilator-associated pneumonia.Frontiers in cellular and infection microbiology · 2026Article
- Gut microbiome in sepsis: from dysbiotic biomarker to precision and palliative decision-making.Frontiers in medicine · 2026Article
- The gastrointestinal microbiome in critical illness: A Clinician's guide to mechanisms, emerging tools, and therapeutic questions.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Review
- T1-T2 Interplay in the Complex Immune Landscape of Severe Asthma.Immunological reviews · 2025Review
- Longitudinal multicompartment characterization of host-microbiota interactions in patients with acute respiratory failure.Nature communications · 2024Article
- Skin dysbiosis and loss of microbiome site specificity in critically ill patients.Microbiology spectrum · 2024Observational
- Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- An open window: the crucial role of the gut-brain axis in neurodevelopmental outcomes post-neurocritical illness.Frontiers in pediatrics · 2024Article
- Article
- Dose-response relationship between diarrhea quantity and mortality in critical care patients: A retrospective cohort study.PloS one · 2023Article
- Article
- Chronic Critical Illness: Current Aspects of the Problem (Review).Sovremennye tekhnologii v meditsine · 2022Review
- Gut microbiome in acute pancreatitis: A review based on current literature.World journal of gastroenterology · 2021Review
- Plasma 1,3-β-d-glucan levels predict adverse clinical outcomes in critical illness.JCI insight · 2021Article
- Sepsis, Cytokine Storms, and Immunopathology: The Divide between Neonates and Adults.ImmunoHorizons · 2021Article
- Immune Modulation in Critically Ill Septic Patients.Medicina (Kaunas, Lithuania) · 2021Review
- Effects of a perioperative antibiotic and veterinary probiotic on fecal dysbiosis index in dogs.The Canadian veterinary journal = La revue veterinaire canadienne · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Complex microbial communities within the human body, constituting the microbiome, have a broad impact on human health and disease. A growing body of research now examines the role of the microbiome in patients with critical illness, such as sepsis and acute respiratory failure. In this article, we provide an introduction to microbiome concepts and terminology and we systematically review the current evidence base of the critical-illness microbiome, including 51 studies in animal models and pediatric and adult critically ill patients. We further examine how this emerging scientific discipline may transform the way we manage infectious and inflammatory diseases in intensive care units. The evolving molecular, culture-independent techniques offer the ability to study microbial communities in unprecedented depth and detail, and in the short-term, may enable us to diagnose and treat infections in critical care more precisely and effectively. Longer term, these tools may also give us insights in the underlying pathophysiology of critical illness and reveal previously unsuspected targets for innovative, microbiome-targeted therapeutics. We finally propose a roadmap for future studies in the field for transforming critical care from its current isolated focus on the host to a more personalized paradigm addressing both human and microbial contributions to critical illness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.