ReviewAgeing research reviews2017
Aging of cerebral white matter.
Review in Ageing research reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
135 citing papers in PubMed, 1 synthesis or guideline pooled it, 255 citations in OpenAlex.
- Lower brain glucose metabolism in normal ageing is predominantly frontal and temporal: A systematic review and pooled effect size and activation likelihood estimates meta-analyses.Human brain mapping · 2023Pooled it
- Trial
- Advanced Brain Ageing Associated with Migraine and Post-Traumatic Headache: A Deep Learning Study.Neurology open access · 2026Article
- Aging-related lateral ventricular shape changes and corresponding mechanical loading derived from longitudinal image registration.Biomechanics and modeling in mechanobiology · 2026Article
- Region-specific transcriptional signatures of brain aging in the absence of neuropathology at the single-cell level.npj aging · 2026Article
- Article
- Multiparametric CEST and Z-spectrum analysis proton (ZAP) as biomarkers of human brain aging.Scientific reports · 2026Article
- Interplay Between Autophagy, Cellular Senescence, and Brain Aging: Neuroprotective Implications of Intermittent Fasting.Cellular and molecular neurobiology · 2026Review
- The association between Ankle Brachial Index (ABI) and cognitive impairment in geriatric patients at Dr Cipto Mangunkusumo Hospital Jakarta.BMC geriatrics · 2026Article
- Pontine pathology mediates common symptoms of blast-induced chronic mild traumatic brain injury.Brain communications · 2026Article
- Risk factors for postoperative cognitive dysfunction in geriatric trauma: a dual-pathway perspective.Frontiers in aging neuroscience · 2026Article
- PHGDH-mediated serine synthesis reduces oligodendrocyte death by sustaining GSH and NADPH levels after brain ischemia.Frontiers in pharmacology · 2026Article
- Molecular Mechanisms Behind Organ-Related Aging and Regulatory Effects of Natural Therapeutics.Cell biochemistry and biophysics · 2025Review
- Birefringence microscopy enables rapid, label-free quantification of myelin debris following induced cortical injury.Neurophotonics · 2025Article
- Aging and the Spectral Properties of Brain Hemodynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- The cellular associates of late life changes in white matter microstructure.bioRxiv : the preprint server for biology · 2025Article
- Imaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review.Neuroscience and biobehavioral reviews · 2025Review
- Impaired capillary-venous drainage contributes to gliosis and demyelination in mouse white matter during aging.Nature neuroscience · 2025Article
- Region-Specific Transcriptional Signatures of Brain Aging in the Absence of Neuropathology at the Single-cell Level.bioRxiv : the preprint server for biology · 2025Article
75 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
White matter (WM) occupies a large volume of the human cerebrum and is mainly composed of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are the structural foundation for efficient neurotransmission between cortical and subcortical areas. Similar to neuron-enriched gray matter areas, WM undergoes a series of changes during the process of aging. WM malfunction can induce serious neurobehavioral and cognitive impairments. Thus, age-related changes in WM may contribute to the functional decline observed in the elderly. In addition, aged WM becomes more susceptible to neurological disorders, such as stroke, traumatic brain injury (TBI), and neurodegeneration. In this review, we summarize the structural and functional alterations of WM in natural aging and speculate on the underlying mechanisms. We also discuss how age-related WM changes influence the progression of various brain disorders, including ischemic and hemorrhagic stroke, TBI, Alzheimer's disease, and Parkinson's disease. Although the physiology of WM is still poorly understood relative to gray matter, WM is a rational therapeutic target for a number of neurological and psychiatric conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.