ArticleInternational journal of biological macromolecules2017
Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses.
Article in International journal of biological macromolecules, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Review
- Natural Products and Health Care Functions ofCurrent issues in molecular biology · 2025Review
- Review
- A review on the cultivation, bioactive compounds, health-promoting factors and clinical trials of medicinal mushrooms Taiwanofungus camphoratus, Inonotus obliquus and Tropicoporus linteus.Fungal biology and biotechnology · 2024Review
- Evaluation of the Polysaccharide "Immeran" Activity inViruses · 2024Article
- NewPolymers · 2023Article
- Chaga mushroom: a super-fungus with countless facets and untapped potential.Frontiers in pharmacology · 2023Review
- A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19.Food chemistry advances · 2022Review
- Polysaccharide derived fromAmerican journal of translational research · 2022Article
- The Mechanisms of Lipid Vesicle Fusion Inhibition by Extracts of Chaga and Buckthorn Leaves.Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology · 2022Article
- Targeting SARS-CoV-2 with Chaga mushroom: An in silico study toward developing a natural antiviral compound.Food science & nutrition · 2021Article
- Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus.International journal of biological macromolecules · 2021Review
- Review
- Recent Developments inPolymers · 2021Review
- Review
- Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.PloS one · 2021Article
- The Antiviral Activity of Bacterial, Fungal, and Algal Polysaccharides as Bioactive Ingredients: Potential Uses for Enhancing Immune Systems and Preventing Viruses.Frontiers in nutrition · 2021Review
- Nitazoxanide protects cats from feline calicivirus infection and acts synergistically with mizoribine in vitro.Antiviral research · 2020Article
- Anti-feline immunodeficiency virus reverse transcriptase properties of some medicinal and edible mushrooms.Veterinary world · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. Using cell models of feline calicivirus (FCV), we demonstrated that IOP treatment was capable of exhibiting anti-FCV strain F9 activity in cell-based assays and also showed low cytotoxicity. Investigation of the mechanism of action of the compound revealed that IOP treatment induces its inhibitory actions directly on virus particles through blocking viral binding/absorpting. The inhibitory activity against other FCV isolates from China was also identified. More importantly, we found that IOP exhibited broad-spectrum antiviral activity against the feline herpesvirus 1, feline influenza virus H3N2 and H5N6, feline panleukopenia virus and feline infectious peritonitis virus that can contribute to respiratory and gastrointestinal diseases in cats. These findings suggest that IOP may be a potential broad-spectrum antiviral drug against feline viruses.
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Registered trials
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