Evidence map›Paper›PMID 27865893›Full record

ArticleToxicology2016

Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain.

Toby B Cole, Jacki Coburn, Khoi Dao, Pam Roqué, Yu-Chi Chang, Vrinda Kalia, Tomas R Guilarte, Jennifer Dziedzic, Lucio G Costa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Neuroendocrine contribution to sex-related variations in adverse air pollution health effects.Journal of toxicology and environmental health. Part B, Critical reviews · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Air Pollution: Possible Interaction between the Immune and Nervous System?International journal of environmental research and public health · 2022
    Review
  17. Article
  18. Review
  19. Mental and Physical Stress Responses to Personal Ultrafine Particle Exposure in Adolescents.International journal of environmental research and public health · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Toby B ColeDept. of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Center on Human Development and Disability, University of Washington, Seattle, WA, USA.
Jacki CoburnDept. of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Khoi DaoDept. of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Pam RoquéDept. of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Yu-Chi ChangDept. of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Vrinda KaliaDept. of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Tomas R GuilarteDept. of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Jennifer DziedzicDept. of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Lucio G CostaDept. of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Dept. of Neuroscience, University of Parma, Italy. Electronic address: lgcosta@u.washington.edu.
University of Washington · USColumbia University · US

Funding

WILDLIFE BIOMARKER APPLICATIONS TO REMEDIATION DECISION MAKINGP42ES004696 · NIEHS · UNIVERSITY OF WASHINGTON · PI GALLAGHER, EVAN P · 1987 to 2021
$51.2M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5M
Environmetal Pathology/Toxicology Training ProgramT32ES007032 · NIEHS · UNIVERSITY OF WASHINGTON · PI FAUSTMAN, ELAINE M, ROSENFELD, MICHAEL E · 1985 to 2023
$10.7M
ENVIRONMENTAL TOXICOLOGY PRE/POST DOCTORAL RES.TRAININGT32ES007062 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 1985 to 2026
$10.5M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI DOHERTY, DANIEL · 2014 to 2019
$7.9M
TSPO and Neuroinflammation in Alzheimer's DiseaseR01ES007062 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI GUILARTE, TOMAS R · 1995 to 2023
$7.3M
Air pollution and the brain: gender as an important determinant of susceptibilityR01ES022949 · NIEHS · UNIVERSITY OF WASHINGTON · PI COSTA, LUCIO G · 2013 to 2017
$1.7M
NICHD NIH HHS U54 HD083091NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P42 ES004696NIEHS NIH HHS R01 ES007062NIEHS NIH HHS R01 ES022949NIEHS NIH HHS T32 ES007032NIEHS NIH HHS T32 ES007062
6 · The paper itself

Abstract

In addition to increased morbidity and mortality caused by respiratory and cardiovascular diseases, air pollution may also contribute to central nervous system (CNS) diseases. Traffic-related air pollution is a major contributor to global air pollution, and diesel exhaust (DE) is its most important component. DE contains more than 40 toxic air pollutants and is a major constituent of ambient particulate matter (PM), particularly of ultrafine-PM. Limited information suggests that exposure to DE may cause oxidative stress and neuroinflammation in the CNS. We hypothesized that males may be more susceptible than females to DE neurotoxicity, because of a lower level of expression of paraoxonase 2 (PON2), an intracellular anti-oxidant and anti-inflammatory enzyme. Acute exposure of C57BL/6 mice to DE (250-300μg/m

Indexed as

Air PollutantsAnimalsAryldialkylphosphataseBrainBrain ChemistryCytokinesFemaleGenetic VariationGlutamate-Cysteine LigaseInflammationMaleMiceMice, Inbred C57BLMice, KnockoutNeurotoxicity SyndromesOxidative StressAir PollutantsAryldialkylphosphataseCytokinesGlutamate-Cysteine LigaseParticulate MatterPON2 protein, mouseVehicle EmissionsAir pollutionDiesel exhaustGenetic susceptibilityMicroglia activationNeuro-inflammationNeurotoxicityOxidative stressSex differences

Identifiers

PMID27865893
PMCPMC5154914
OpenAlexW2552124963

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.