Evidence map›Paper›PMID 27865696›Full record

Trial reportJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2017

Strength Training for Skeletal Muscle Endurance after Stroke.

Frederick M Ivey, Steven J Prior, Charlene E Hafer-Macko, Leslie I Katzel, Richard F Macko, Alice S Ryan

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00827827 (Strength Training for Skeletal Muscle Adaptation After Stroke), which is not on this map. Cited by 21 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 6 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00827827 nacompletednot on this map

Strength Training for Skeletal Muscle Adaptation After Stroke

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2009 to 2018Enrolled38ConditionsStrokeArmsExercise- Strength Training, Exercise- Stretching Control
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Resistance training for people with stroke.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
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  5. Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2020
    Pooled it
  6. Pooled it
  7. Trial
  8. Article
  9. Review
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  11. Article
  12. Review
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  17. Review
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  19. Cyclical blood flow restriction resistance exercise: a potential parallel to remote ischemic preconditioning?American journal of physiology. Regulatory, integrative and comparative physiology · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Frederick M IveyDepartment of Veterans Affairs and Veterans Affairs Medical Center, Maryland Exercise and Robotics Center of Excellence (MERCE), Geriatric Research, Education and Clinical Center (GRECC), University of Maryland School of Medicine, Baltimore, Maryland; Department of Neurology. Electronic address: fivey@grecc.umaryland.edu.
Steven J PriorDepartment of Veterans Affairs and Veterans Affairs Medical Center, Maryland Exercise and Robotics Center of Excellence (MERCE), Geriatric Research, Education and Clinical Center (GRECC), University of Maryland School of Medicine, Baltimore, Maryland; Department of Medicine, Division of Gerontology and Geriatric Medicine.
Charlene E Hafer-MackoDepartment of Veterans Affairs and Veterans Affairs Medical Center, Maryland Exercise and Robotics Center of Excellence (MERCE), Geriatric Research, Education and Clinical Center (GRECC), University of Maryland School of Medicine, Baltimore, Maryland; Department of Neurology.
Leslie I KatzelDepartment of Veterans Affairs and Veterans Affairs Medical Center, Maryland Exercise and Robotics Center of Excellence (MERCE), Geriatric Research, Education and Clinical Center (GRECC), University of Maryland School of Medicine, Baltimore, Maryland; Department of Medicine, Division of Gerontology and Geriatric Medicine.
Richard F MackoDepartment of Veterans Affairs and Veterans Affairs Medical Center, Maryland Exercise and Robotics Center of Excellence (MERCE), Geriatric Research, Education and Clinical Center (GRECC), University of Maryland School of Medicine, Baltimore, Maryland; Department of Neurology.
Alice S RyanDepartment of Veterans Affairs and Veterans Affairs Medical Center, Maryland Exercise and Robotics Center of Excellence (MERCE), Geriatric Research, Education and Clinical Center (GRECC), University of Maryland School of Medicine, Baltimore, Maryland; Department of Medicine, Division of Gerontology and Geriatric Medicine.
Geriatric Research Education and Clinical Center · USNational Center for Geriatrics and Gerontology · JP

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
Effects of Aerobic Exerise on EPCs and Vascular Dysfunction in Aging and T2DMK23AG040775 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI PRIOR, STEVEN J · 2012 to 2014
$532k
NIA NIH HHS K23 AG040775NIA NIH HHS P30 AG028747
6 · The paper itself

Abstract

background and purposeInitial studies support the use of strength training (ST) as a safe and effective intervention after stroke. Our previous work shows that relatively aggressive, higher intensity ST translates into large effect sizes for paretic and non-paretic leg muscle volume, myostatin expression, and maximum strength post-stroke. An unanswered question pertains to how our unique ST model for stroke impacts skeletal muscle endurance (SME). Thus, we now report on ST-induced adaptation in the ability to sustain isotonic muscle contraction.

methodsFollowing screening and baseline testing, hemiparetic stroke participants were randomized to either ST or an attention-matched stretch control group (SC). Those in the ST group trained each leg individually to muscle failure (20 repetition sets, 3× per week for 3 months) on each of three pneumatic resistance machines (leg press, leg extension, and leg curl). Our primary outcome measure was SME, quantified as the number of submaximal weight leg press repetitions possible at a specified cadence. The secondary measures included one-repetition maximum strength, 6-minute walk distance (6MWD), 10-meter walk speeds, and peak aerobic capacity (VO

resultsST participants (N = 14) had significantly greater SME gains compared with SC participants (N = 16) in both the paretic (178% versus 12%, P < .01) and non-paretic legs (161% versus 12%, P < .01). These gains were accompanied by group differences for 6MWD (P < .05) and VO

conclusionOur ST regimen had a large impact on the capacity to sustain submaximal muscle contraction, a metric that may carry more practical significance for stroke than the often reported measures of maximum strength.

Indexed as

Stroke RehabilitationAdultAgedAge FactorsFemaleFollow-Up StudiesHumansMaleMiddle AgedMuscle, SkeletalMuscle StrengthOxygen ConsumptionResistance TrainingStrokeTreatment OutcomeWalkingenduranceexercisestrength trainingStroke recoverystroke rehabilitation

Identifiers

PMID27865696
PMCPMC5947878
OpenAlexW2554308839

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.