Trial reportAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017
Phosphorus Additives and Albuminuria in Early Stages of CKD: A Randomized Controlled Trial.
Trial report in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- The impact of dietary phosphorus supplementation on postprandial metabolic outcomes: a systematic review.Journal of nutritional science · 2026Pooled it
- Dietary Potassium Intake and Risk of Chronic Kidney Disease Progression in Predialysis Patients with Chronic Kidney Disease: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Dietary Magnesium Intake and Proteinuria: Is There a Relationship?Biological trace element research · 2024Trial
- A Low-Sodium DASH Dietary Pattern Affects Serum Markers of Inflammation and Mineral Metabolism in Adults with Elevated Blood Pressure.The Journal of nutrition · 2021Trial
- Effects of Lowering Dietary Phosphorus Additive Intake on Mineral Metabolism in Adults with and without CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Causal effects of serum calcium, phosphate, and 25-hydroxyvitamin D on kidney function: a genetic correlation, pleiotropic analysis, and Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Dietary macrominerals: Updated review of their role and orchestration in human nutrition throughout the life cycle with sex differences.Current research in food science · 2023Review
- Review
- Dietary Micronutrients and Risk of Chronic Kidney Disease: A Cohort Study with 12 Year Follow-Up.Nutrients · 2021Article
- Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets.Frontiers in physiology · 2021Review
- Mediation of the relationship between proteinuria and serum phosphate: Insight from the KNOW-CKD study.PloS one · 2020Article
- Diet and Chronic Kidney Disease.Advances in nutrition (Bethesda, Md.) · 2019Review
- Strategies for Phosphate Control in Patients With CKD.Kidney international reports · 2019Review
- Nutritional treatment of advanced CKD: twenty consensus statements.Journal of nephrology · 2018Article
- Association between Dietary Mineral Intake and Chronic Kidney Disease: The Health Examinees (HEXA) Study.International journal of environmental research and public health · 2018Article
- Hyperparathyroidism and increased fractional excretion of phosphate predict allograft loss in long-term kidney transplant recipients.Clinical and experimental nephrology · 2017Article
- Dietary Phosphorus Intake and the Kidney.Annual review of nutrition · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLittle is known about the effects of phosphorus additives on patients with kidney disease. STUDY
designRandomized, double-blind, crossover trial. SETTING &
participants31 adults with early stages of presumed chronic kidney disease (estimated glomerular filtration rate ≥ 45mL/min/1.73m
interventionHigher versus lower phosphorus intake for 3 weeks. Higher phosphorus intake was achieved by the addition of commercially available diet beverages and breakfast bars to diet. OUTCOMES: Change in 24-hour urine albumin excretion and plasma fibroblast growth factor 23 level. MEASUREMENTS: Two 24-hour urine collections and a single fasting blood draw at the end of each period.
resultsMean baseline values for phosphorus intake, 24-hour urine phosphorus excretion, and estimated glomerular filtration rate were 1,113±549 (SD) mg/d, 688±300mg/d, and 74.6±22.0mL/min/1.73m LIMITATIONS: Small sample size, short duration of intervention, changes in background diet during the intervention.
conclusionsA 3-week consumption of higher phosphorus food additives did not significantly increase albuminuria. Further studies are needed to confirm these results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.