ReviewBiological psychiatry2017
Neurophysiology and Regulation of the Balance Between Excitation and Inhibition in Neocortical Circuits.
Review in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
112 citing papers in PubMed, 1 synthesis or guideline pooled it, 206 citations in OpenAlex.
- Glutamatergic Modulation of Brain Function in Psychosis: A Systematic Review of Neuroimaging Studies.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Pooled it
- TMS-EEG signatures of glutamatergic neurotransmission in human cortex.Scientific reports · 2021Trial
- Alterations in interhemispheric gamma-band connectivity are related to the emergence of auditory verbal hallucinations in healthy subjects during NMDA-receptor blockade.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Differential glutamate modulation in the anterior mid-cingulate cortex of healthy adults during inhibitory motor control utilizing a novel interleaved baseline control condition: a ¹H fMRS study.Brain structure & function · 2026Article
- Hemispheric Dissociation Revealed by Attentional Isolation and Transcranial Random Noise Stimulation.Journal of cognitive neuroscience · 2026Article
- Rethinking EEG biomarkers of brain disorders: a transdiagnostic dimensional view.Translational psychiatry · 2026Review
- Effects of pharmacological modulation of cortical excitability on resting-state EEG PAC in humans.Scientific reports · 2026Article
- Effects of age and musical training on resting-state periodic oscillatory brain activity.GeroScience · 2026Article
- Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges.Nature neuroscience · 2026Article
- Deep Brain Stimulation Induces Antidepressant Effects by Restoring High-Fidelity Communication in the BNST-NAc Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- From neuroinflammation to neural inference: computational psychiatry meets precision medicine.Schizophrenia (Heidelberg, Germany) · 2026Review
- Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy.Epilepsia · 2026Article
- Intensity-dependent tACS entrainment effects in a cortical microcircuit: a computational study.Scientific reports · 2026Article
- The Tip-of-the-Tongue Phenomenon: Cognitive, Neural, and Neurochemical Perspectives.Biomedicines · 2026Review
- Article
- Genetic Tools in Rodents to Study Cannabinoid Functions.Current topics in behavioral neurosciences · 2026Review
- Methodology for human-induced pluripotent stem cell-derived excitatory and inhibitory neuron coculture with astrocytes for Alzheimer's disease modelling.Brain communications · 2026Article
- GABAFrontiers in pharmacology · 2026Review
- O-GlcNAc transferase controls excitatory synapse development and AMPA receptor expression in an activity-dependent manner.Frontiers in cellular neuroscience · 2026Article
- A novel image-based neuronal network model framework for understanding visual multistability and neurological disorders.Frontiers in computational neuroscience · 2026Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Brain function relies on the ability of neural networks to maintain stable levels of activity, while experiences sculpt them. In the neocortex, the balance between activity and stability relies on the coregulation of excitatory and inhibitory inputs onto principal neurons. Shifts of excitation or inhibition result in altered excitability impaired processing of incoming information. In many neurodevelopmental and neuropsychiatric disorders, the excitability of local circuits is altered, suggesting that their pathophysiology may involve shifts in synaptic excitation, inhibition, or both. Most studies focused on identifying the cellular and molecular mechanisms controlling network excitability to assess whether they may be altered in animal models of disease. The impact of changes in excitation/inhibition balance on local circuit and network computations is not clear. Here we report findings on the integration of excitatory and inhibitory inputs in healthy cortical circuits and discuss how shifts in excitation/inhibition balance may relate to pathological phenotypes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.