Evidence map›Paper›PMID 27865363›Full record

ArticleOral oncology2016

Pathology-based staging for HPV-positive squamous carcinoma of the oropharynx.

B H Haughey, P Sinha, D Kallogjeri, R L Goldberg, J S Lewis, J F Piccirillo, R S Jackson, E J Moore, M Brandwein-Gensler, S J Magnuson and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
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  9. [Advances in the diagnosis and prognosis of extranodal extension in head and neck squamous cell carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: a consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Article
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  20. Identification and clinical validation of gene signatures with grade and survival in head and neck carcinomas.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

B H HaugheyHead and Neck Surgery, Florida Hospital Celebration Health, Celebration, FL, USA; Department of Surgery, University of Auckland Faculty of Medicine and Health Sciences, Auckland, New Zealand. Electronic address: Bruce.Haughey.MD@flhosp.org.
P SinhaOtolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
D KallogjeriOtolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
R L GoldbergOtolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
J S LewisPathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
J F PiccirilloOtolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
R S JacksonOtolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
E J MooreOtolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA.
M Brandwein-GenslerPathology and Anatomical Sciences, SUNY at the University at Buffalo, Buffalo, NY, USA.
S J MagnusonHead and Neck Surgery, Florida Hospital Celebration Health, Celebration, FL, USA.
W R CarrollOtolaryngology-Head and Neck Surgery, University of Alabama, Birmingham, AL, USA.
T M JonesOtolaryngology-Head and Neck Surgery, University of Liverpool, UK; Aintree University Hospitals NHS Foundation Trust, Liverpool, UK.
M D WilkieOtolaryngology-Head and Neck Surgery, University of Liverpool, UK; Aintree University Hospitals NHS Foundation Trust, Liverpool, UK.
A LauOtolaryngology-Head and Neck Surgery, University of Liverpool, UK; Aintree University Hospitals NHS Foundation Trust, Liverpool, UK.
N S UpileOtolaryngology-Head and Neck Surgery, University of Liverpool, UK; Aintree University Hospitals NHS Foundation Trust, Liverpool, UK.
Jon SheardAintree University Hospitals NHS Foundation Trust, Liverpool, UK; Pathology, University of Liverpool, UK.
J LancasterAintree University Hospitals NHS Foundation Trust, Liverpool, UK.
S TandonAintree University Hospitals NHS Foundation Trust, Liverpool, UK.
M RobinsonCentre for Oral Health Research, Newcastle University, Framlington Place, Newcastle-upon-Tyne, UK.
D HusbandClatterbridge Cancer Centre, Wirral, UK.
I GanlyHead and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
J P ShahHead and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
D M BrizelRadiation Oncology, Duke University Medical Center, Durham, NC, USA.
B O'SullivanRadiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
J A RidgeHead and Neck Surgery, Fox Chase Cancer Center, Philadelphia, PA, USA.
W M LydiattClinical Professor, Creighton Department of Surgery, Omaha, NE, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Cancer Research UK 17161Medical Research Council MR/N005872/1NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

objectiveThe rapid worldwide rise in incidence of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has generated studies confirming this disease as an entity distinct from traditional OPSCC. Based on pathology, surgical studies have revealed prognosticators specific to HPV-positive OPSCC. The current AJCC/UICC staging and pathologic nodal (pN)-classification do not differentiate for survival, demonstrating the need for new, HPV-specific OPSCC staging. The objective of this study was to define a pathologic staging system specific to HPV-positive OPSCC.

methodsData were assembled from a surgically-managed, p16-positive OPSCC cohort (any T, any N, M0) of 704 patients from five cancer centers. Analysis was performed for (a) the AJCC/UICC pathologic staging, (b) newly published clinical staging for non-surgically managed HPV-positive OPSCC, and (c) a novel, pathology-based, "HPVpath" staging system that combines features of the primary tumor and nodal metastases.

resultsA combination of AJCC/UICC pT-classification and pathology-confirmed metastatic node count (⩽4 versus ⩾5) yielded three groups: stages I (pT1-T2, ⩽4 nodes), II (pT1-T2, ⩾5 nodes; pT3-T4, ⩽4 nodes), and III (pT3-T4, ⩾5 nodes), with incrementally worse prognosis (Kaplan-Meier overall survival of 90%, 84% and 48% respectively). Existing AJCC/UICC pathologic staging lacked prognostic definition. Newly published HPV-specific clinical stagings from non-surgically managed patients, although prognostic, showed lower precision for this surgically managed cohort.

conclusionsThree loco-regional "HPVpath" stages are identifiable for HPV-positive OPSCC, based on a combination of AJCC/UICC primary tumor pT-classification and metastatic node count. A workable, pathologic staging system is feasible to establish prognosis and guide adjuvant therapy decisions in surgically-managed HPV-positive OPSCC.

Indexed as

AgedAlphapapillomavirusCarcinoma, Squamous CellDisease-Free SurvivalHead and Neck NeoplasmsHumansMiddle AgedPrognosisSquamous Cell Carcinoma of Head and NeckHead and neck cancerHuman papillomavirusOropharynx cancerP16 geneP16-positivePathologic stagingStaging

Identifiers

PMID27865363
PMCPMC5523818

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.