Evidence map›Paper›PMID 27865151›Full record

ArticleDrug and alcohol dependence2017

Effects of the benzodiazepine GABA

August F Holtyn, V V N Phani Babu Tiruveedhula, Michael Rajesh Stephen, James M Cook, Elise M Weerts

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. GABAergic compounds for the treatment of alcohol use disorder.International review of neurobiology · 2024
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

August F HoltynJohns Hopkins University School of Medicine, Division of Behavioral Biology, 5510 Nathan Shock Dr, Baltimore, MD 21224, USA.
V V N Phani Babu TiruveedhulaUniversity of Wisconsin-Milwaukee, Department of Chemistry & Biochemistry, 3210 N Cramer St, Milwaukee, WI 53201, USA.
Michael Rajesh StephenUniversity of Wisconsin-Milwaukee, Department of Chemistry & Biochemistry, 3210 N Cramer St, Milwaukee, WI 53201, USA.
James M CookUniversity of Wisconsin-Milwaukee, Department of Chemistry & Biochemistry, 3210 N Cramer St, Milwaukee, WI 53201, USA.
Elise M WeertsJohns Hopkins University School of Medicine, Division of Behavioral Biology, 5510 Nathan Shock Dr, Baltimore, MD 21224, USA. Electronic address: eweerts@jhmi.edu.
University of Wisconsin–Milwaukee · USJohns Hopkins Medicine · USJohns Hopkins University · US

Funding

Preclinical Assessment of Medications for Alcohol AbuseR01AA015971 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI WEERTS, ELISE M · 2007 to 2023
$7.7M
Development of new drugs for asthma by targeting GABA(A) receptors in the lungR01HL118561 · NHLBI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2014 to 2017
$2.0M
Design of New Therapeutic Agents to Treat SchizophreniaR01MH096463 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2013 to 2017
$1.9M
Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3M
NHLBI NIH HHS R01 HL118561NIAAA NIH HHS R01 AA015971NIMH NIH HHS R01 MH096463NINDS NIH HHS R01 NS076517
6 · The paper itself

Abstract

backgroundThe major inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), modulates many of the behavioral effects of alcohol, including sedation, tolerance, and withdrawal. The α1 subunit of the benzodiazepine GABA

methodsEight baboons self-administered alcohol (4% w/v; n=5; alcohol group) or a non-alcoholic beverage (n=3; control group) in Component 3 of a chained schedule of reinforcement. Responses in Component 2 provided indices of motivation to drink (seeking). Doses of 3-ISOPBC (5.0-30.0mg/kg) and vehicle were administered before drinking sessions under both acute and chronic (5day) conditions.

resultsChronic, and not acute, administration of 3-ISOPBC significantly decreased self-administration responses, g/kg alcohol consumed, and the number of drinks in and duration of the first drinking bout in the alcohol group. In the control group, chronic administration of 3-ISOPBC did not significantly decrease any of these measures at any of the doses.

conclusionsThe GABA

Indexed as

Reinforcement, PsychologySelf AdministrationAlcohol DrinkingAnimalsBenzodiazepinesDrug-Seeking BehaviorEthanolGABA-A Receptor Antagonistsgamma-Aminobutyric AcidMaleMotivationPapioTreatment OutcomeBenzodiazepinesEthanolGABA-A Receptor Antagonistsgamma-Aminobutyric Acid3-ISOPBC3-Isopropoxy-β-carboline hydrochlorideAlcoholBaboonSelf-administration

Identifiers

PMID27865151
PMCPMC5183547
OpenAlexW2546750833

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.