ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2017
Psychological Outcomes of Living Liver Donors From a Multicenter Prospective Study: Results From the Adult-to-Adult Living Donor Liver Transplantation Cohort Study2 (A2ALL-2).
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01619475 (A2ALL), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A2ALL: Adult-to-Adult Living Transplant Cohort Study
Who cites it
17 citing papers in PubMed, 66 citations in OpenAlex.
- Adult Post-operative Mental Health Outcomes Following Abdominal and Orthopedic Surgeries: A Scoping Review.Cureus · 2026Review
- Should All Living Donors Receive Equal Priority in Organ Allocation? An Equality of Opportunity Perspective.Journal of bioethical inquiry · 2026Article
- The relationship between spiritual well-being, state anxiety, and psychological resilience among cross-matched liver transplant donors in Turkey.BMC psychology · 2026Article
- Adaptation of living donors after liver transplantation in South Korea: an integrative review.Journal of Korean biological nursing science · 2026Article
- Era of metabolic dysfunction-associated steatotic liver disease and impact on the liver donor pool.World journal of gastroenterology · 2025Review
- Current perspectives on living donor selection in liver transplantation.Updates in surgery · 2025Review
- Serial Living Solid Organ Donation: An Ethical Analysis.Journal of evaluation in clinical practice · 2025Article
- Family-Related Motivation and Regret Intensity Among Family Liver Donors by Type of Family Relationship.Annals of transplantation · 2025Article
- Alternate Choice Organ Counselling in Altruistic Non-Directed Solid Organ Donation: An Ethical Analysis.Journal of evaluation in clinical practice · 2025Article
- The lived experience of living liver donors: A meta-synthesis of qualitative studies.BMC nursing · 2024Article
- Donor and Donation Images (DDI)-A Scoping Review of What We Know and What We Don't.Journal of clinical medicine · 2023Article
- The care of donors and recipients in adult living donor liver transplantation.BJA education · 2022Review
- Clinical Features and Long-Term Outcomes of Living Donors of Liver Transplantation Who Developed Psychiatric Disorders.Annals of transplantation · 2020Article
- Anonymous live liver donor: the Good Samaritan Stranger.Nature reviews. Gastroenterology & hepatology · 2019Article
- Psychosocial Issues Related to Donor's Decision-Making in Living Donor Liver Transplantation.Annals of transplantation · 2019Article
- Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2018Observational
- Prevalence and Predictors of Patient-Reported Long-term Mental and Physical Health After Donation in the Adult-to-Adult Living-Donor Liver Transplantation Cohort Study.Transplantation · 2018Article
Corrections and comments
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Authors and funding
16 authors at 12 institutions in 2 countries.
Funding
Abstract
Although single-center and cross-sectional studies have suggested a modest impact of liver donation on donor psychological well-being, few studies have assessed these outcomes prospectively among a large cohort. We conducted one of the largest, prospective, multicenter studies of psychological outcomes in living liver donors within the Adult-to-Adult Living Donor Liver Transplantation Cohort Study2 (A2ALL-2) consortium. In total, 271 (91%) of 297 eligible donors were interviewed at least once before donation and at 3, 6, 12, and 24 mo after donation using validated measures. We found that living liver donors reported low rates of major depressive (0-3%), alcohol abuse (2-5%), and anxiety syndromes (2-3%) at any given assessment in their first 2 years after donation. Between 4.7% and 9.6% of donors reported impaired mental well-being at various time points. We identified significant predictors for donors' perceptions of being better people and experiencing psychological growth following donation, including age, sex, relationship to recipient, ambivalence and motivation regarding donation, and feeling that donation would make life more worthwhile. Our results highlight the need for close psychosocial monitoring for those donors whose recipients died (n=27); some of those donors experienced guilt and concerns about responsibility. Careful screening and targeted, data-driven follow-up hold promise for optimizing psychological outcomes following this procedure for potentially vulnerable donors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.