Evidence map›Paper›PMID 27865015›Full record

ArticleAddiction (Abingdon, England)2017

Cannabis use during treatment for alcohol use disorders predicts alcohol treatment outcomes.

Meenakshi Sabina Subbaraman, Jane Metrik, Deidre Patterson, Robert Swift

Abstract read
In one paragraph

Article in Addiction (Abingdon, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

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  6. Momentary cannabis effects on alcohol use among adults trying to quit or cut back on drinking.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026
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  8. The Cannabinoid System as a Potential Novel Target for Alcohol-Associated Liver Disease: A Propensity-Matched Cohort Study.Liver international : official journal of the International Association for the Study of the Liver · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Meenakshi Sabina SubbaramanAlcohol Research Group, Public Health Institute, Emeryville, CA, USA.
Jane MetrikCenter for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, USA.
Deidre PattersonAlcohol Research Group, Public Health Institute, Emeryville, CA, USA.
Robert SwiftCenter for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, USA.

Funding

How Cannabis Use Affects Alcohol Treatment OutcomesR21AA023039 · NIAAA · PUBLIC HEALTH INSTITUTE · PI SUBBARAMAN, MEENAKSHI S · 2015 to 2016
$335k
NIAAA NIH HHS R21 AA023039
6 · The paper itself

Abstract

aimsTo compare post-treatment alcohol use between those who use cannabis and those who abstain during treatment for alcohol use disorders (AUD); and to examine potential cannabis use thresholds by comparing post-treatment alcohol use between four frequency groups of cannabis users relative to abstainers.

designSecondary analyses of the Combined Pharmacotherapies and Behavioral Interventions (COMBINE) Study, a randomized control trial of AUD treatments. The current study compares longitudinal drinking data between those who used cannabis versus those who abstained during COMBINE treatment.

settingThe COMBINE Study treatments were delivered on an out-patient basis for 16 weeks. The current analyses include 206 cannabis users and 999 cannabis abstainers.

participantsAll participants met diagnosis of primary alcohol dependence (n = 1383). MEASUREMENTS: Primary exposures were any cannabis use and quartiles of cannabis use (Q1: 1-4 use days during treatment, Q2: 5-9 days, Q3: 10-44 days, Q4: 45-112 days). Outcomes were percentage of days abstinent from alcohol (PDA), drinks per drinking day (DPDD) and percentage of heavy drinking days (PHD), all measured at treatment end and 1 year post-treatment.

findingsCompared with no cannabis use, any cannabis use during treatment was associated with 4.35% [95% confidence interval (CI) = -8.68, -0.02], or approximately 4 fewer alcohol abstinent days at the end of treatment. This association weakened by 1 year post-treatment (95% CI = -9.78, 0.54). Compared with no cannabis use, only those in the second quartile of cannabis use (those who used once or twice per month during treatment) had 8.81% (95% CI = -17.00, -0.63), or approximately 10 fewer days alcohol abstinent at end of treatment, and 11.82% (95% CI = -21.56, -2.07), or approximately 13 fewer alcohol abstinent days 1 year post-treatment. Neither any cannabis use nor quartiles were associated with DPDD or PHD at either time-point.

conclusionsAmong individuals in alcohol treatment, any cannabis use (compared with none) is related to a significantly lower percentage of days abstinent from alcohol post-treatment, although only among those who used cannabis once or twice per month.

Indexed as

Alcohol AbstinenceBehavior TherapyAcamprosateAdultAlcohol DeterrentsAlcoholismCombined Modality TherapyComorbidityDrug Therapy, CombinationFemaleHumansMaleMarijuana UseMiddle AgedNaltrexoneNarcotic AntagonistsAcamprosateAlcohol DeterrentsNaltrexoneNarcotic AntagonistsTaurineAlcoholalcohol dependencealcohol use disorderscannabismarijuanatreatment

Identifiers

PMID27865015
PMCPMC5339049

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.