Evidence map›Paper›PMID 27865007›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2016

Anisotropic Materials for Skeletal-Muscle-Tissue Engineering.

Soumen Jana, Sheeny K Lan Levengood, Miqin Zhang

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed.

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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Soumen JanaDepartment of Materials Science & Engineering, University of Washington, Seattle, Washington, 98195, USA.
Sheeny K Lan LevengoodDepartment of Materials Science & Engineering, University of Washington, Seattle, Washington, 98195, USA.
Miqin ZhangDepartment of Materials Science & Engineering, University of Washington, Seattle, Washington, 98195, USA.

Funding

Nanotechnology and Physical Science Training Program in Cancer ResearchT32CA138312 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2009 to 2013
$1.5M
New 3D tumor models to rapidly test drugs for brain cancer therapyR01CA172455 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2013 to 2016
$1.1M
NCI NIH HHS R01 CA172455NCI NIH HHS T32 CA138312
6 · The paper itself

Abstract

Repair of damaged skeletal-muscle tissue is limited by the regenerative capacity of the native tissue. Current clinical approaches are not optimal for the treatment of large volumetric skeletal-muscle loss. As an alternative, tissue engineering represents a promising approach for the functional restoration of damaged muscle tissue. A typical tissue-engineering process involves the design and fabrication of a scaffold that closely mimics the native skeletal-muscle extracellular matrix (ECM), allowing organization of cells into a physiologically relevant 3D architecture. In particular, anisotropic materials that mimic the morphology of the native skeletal-muscle ECM, can be fabricated using various biocompatible materials to guide cell alignment, elongation, proliferation, and differentiation into myotubes. Here, an overview of fundamental concepts associated with muscle-tissue engineering and the current status of muscle-tissue-engineering approaches is provided. Recent advances in the development of anisotropic scaffolds with micro- or nanoscale features are reviewed, and how scaffold topographical, mechanical, and biochemical cues correlate to observed cellular function and phenotype development is examined. Finally, some recent developments in both the design and utility of anisotropic materials in skeletal-muscle-tissue engineering are highlighted, along with their potential impact on future research and clinical applications.

Indexed as

Extracellular MatrixMuscle, SkeletalAnimalsBiocompatible MaterialsCell DifferentiationHumansMuscle Fibers, SkeletalTissue EngineeringTissue ScaffoldsBiocompatible Materialsanisotropic materialsmicropatterned substratesmusclesnanofibersscaffoldstissue engineering

Identifiers

PMID27865007
PMCPMC5253134

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.