ArticleMolecular ecology2017
Recombination rate variation in mice from an isolated island.
Article in Molecular ecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- A high-resolution crossover landscape in Drosophila santomea reveals rapid and concerted evolution of multiple properties of crossing over control.PLoS genetics · 2025Article
- Genetic architecture of individual meiotic crossover rate and distribution in Atlantic Salmon.Scientific reports · 2023Article
- Population structure and inbreeding in wild house mice (Mus musculus) at different geographic scales.Heredity · 2022Article
- Background selection under evolving recombination rates.Proceedings. Biological sciences · 2022Article
- Recombination rates in pigs differ between breeds, sexes and individuals, and are associated with the RNF212, SYCP2, PRDM7, MEI1 and MSH4 loci.Genetics, selection, evolution : GSE · 2022Article
- Meiotic, genomic and evolutionary properties of crossover distribution in Drosophila yakuba.PLoS genetics · 2022Article
- Predicting the Landscape of Recombination Using Deep Learning.Molecular biology and evolution · 2020Article
- A first genetic portrait of synaptonemal complex variation.PLoS genetics · 2019Article
- Connecting theory and data to understand recombination rate evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- The Recombination Landscape in Wild House Mice Inferred Using Population Genomic Data.Genetics · 2017Article
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5 authors.
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Abstract
Recombination rate is a heritable trait that varies among individuals. Despite the major impact of recombination rate on patterns of genetic diversity and the efficacy of selection, natural variation in this phenotype remains poorly characterized. We present a comparison of genetic maps, sampling 1212 meioses, from a unique population of wild house mice (Mus musculus domesticus) that recently colonized remote Gough Island. Crosses to a mainland reference strain (WSB/EiJ) reveal pervasive variation in recombination rate among Gough Island mice, including subchromosomal intervals spanning up to 28% of the genome. In spite of this high level of polymorphism, the genomewide recombination rate does not significantly vary. In general, we find that recombination rate varies more when measured in smaller genomic intervals. Using the current standard genetic map of the laboratory mouse to polarize intervals with divergent recombination rates, we infer that the majority of evolutionary change occurred in one of the two tested lines of Gough Island mice. Our results confirm that natural populations harbour a high level of recombination rate polymorphism and highlight the disparities in recombination rate evolution across genomic scales.
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