ArticleBrain pathology (Zurich, Switzerland)2017
IgG4-related hypophysitis is highly prevalent among cases of histologically confirmed hypophysitis.
Article in Brain pathology (Zurich, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Review
- Immune-Mediated Hypophysitis: An Updated Review.Journal of clinical medicine · 2026Review
- Pitfalls in the management of undiagnosed secondary adrenal insufficiency: a case report and review of the literature.Journal of medical case reports · 2026Review
- Isolated IgG4-related Infundibulo-hypophysitis.JCEM case reports · 2024Article
- [Differential diagnosis and tactics of managing a patient with primary hypophysitis on the example of a clinical case].Problemy endokrinologii · 2024Article
- Inflammatory and Infectious Disorders in Endocrine Pathology.Endocrine pathology · 2023Review
- A rare case of isolated IgG4-related hypophysitis with Rathke's cleft cyst presenting as panhypopituitarism.Endocrinology, diabetes & metabolism case reports · 2023Article
- IgG4-related hypophysitis: a retrospective cohort study.Acta neurochirurgica · 2022Article
- Typing of inflammatory lesions of the pituitary.Pituitary · 2022Article
- Sellar germinoma mimicking IgG4-related hypophysitis: a case report.BMC endocrine disorders · 2022Article
- Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease.The Journal of clinical endocrinology and metabolism · 2022Review
- Immunoglobulin G4 hypophysitis in a 63-year-old woman with no autoimmune history: a case report.Journal of medical case reports · 2021Article
- IgG4-related hypophysitis.Endocrine · 2021Review
- A Case Series of Patients with Isolated IgG4-related Hypophysitis Treated with Rituximab.Journal of the Endocrine Society · 2020Article
- Two cases of immunoglobulin G4 (IgG4)-related hypophysitis diagnosed without pituitary biopsy.Therapeutic advances in endocrinology and metabolism · 2020Article
- Hypophysitis: An update on the novel forms, diagnosis and management of disorders of pituitary inflammation.Best practice & research. Clinical endocrinology & metabolism · 2019Review
- Disease heterogeneity in IgG4-related hypophysitis: report of two histopathologically proven cases and review of the literature.Virchows Archiv : an international journal of pathology · 2019Review
- Neuro-radiological features can predict hypopituitarism in primary autoimmune hypophysitis.Pituitary · 2018Article
- A case series of atypical features of patients with biopsy-proven isolated IgG4-related hypophysitis and normal serum IgG4 levels.Pituitary · 2018Article
- Neurological Manifestations of IgG4-Related Disease.Current treatment options in neurology · 2017Review
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IgG4-related disease is an immune-mediated disease with manifestations in most organ systems among them the pituitary gland. To date, few cases of histologically confirmed cases of IgG-related hypophysitis have been reported. The aim of this study was to retrospectively determine the prevalence of IgG4-related hypophysitis among cases previously diagnosed as primary hypophysitis (lymphocytic hypophysitis, granulomatous hypophysitis and hypophysitis not otherwise specified). Histological and immunohistochemical analysis revealed that 12 of 29 cases (41.4%) previously diagnosed as primary hypophysitis fulfilled the criteria for IgG4-related disease and, thus, IgG4-related hypophysitis should always be considered in the differential diagnosis of primary hypophysitis. All cases of IgG4-related hypophysitis showed a dense lymphoplasmacytic infiltrate with more than 10 IgG4-positive cells per high power field and a ratio of IgG4/IgG-positive cells of more than 40%, whereas storiform fibrosis was an inconsistent histological feature and was also seen in few cases of non-IgG-related hypophysitis, thus lacking sensitivity and specificity. Obliterative phlebitis was not seen in any case. Thus, histological criteria defined for IgG4-related disease in other organs should be modified for IgG4-related hypophysitis, accordingly.
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