ArticleJournal of veterinary internal medicine2017
Hyperhomocysteinemia in Greyhounds and its Association with Hypofolatemia and Other Clinicopathologic Variables.
Article in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Correlation of disease markers with clinical, endoscopic, and histologic findings in dogs with chronic gastrointestinal inflammation.Brazilian journal of veterinary medicine · 2025Article
- Implications of hypocobalaminemia as a negative prognostic marker in juvenile dogs with parvovirus enteritis.Frontiers in veterinary science · 2024Article
- Multiple Origins and Genomic Basis of Complex Traits in Sighthounds.Molecular biology and evolution · 2023Article
- Association of folate concentrations with clinical signs and laboratory markers of chronic enteropathy in dogs.Journal of veterinary internal medicine · 2023Article
- Serum homocysteine concentration in dogs with immunosuppressant-responsive enteropathy.Journal of veterinary science · 2020Article
- Plasma homocysteine concentration in privately owned healthy adult cats: assessment of biological determinants and establishment of a reference interval.Journal of feline medicine and surgery · 2020Article
- Targeted Metabolomics With Ultraperformance Liquid Chromatography-Mass Spectrometry (UPLC-MS) Highlights Metabolic Differences in Healthy and Atopic Staffordshire Bull Terriers Fed Two Different Diets, A Pilot Study.Frontiers in veterinary science · 2020Article
- Review of cobalamin status and disorders of cobalamin metabolism in dogs.Journal of veterinary internal medicine · 2020Review
- Analytical quality assessment and method comparison of immunoassays for the measurement of serum cobalamin and folate in dogs and cats.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2019Article
- Potential mechanism for hyperhomocysteinemia in Greyhound dogs.Journal of veterinary internal medicineArticle
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFolate and cobalamin are essential cofactors for homocysteine (HCY) metabolism. Hyperhomocysteinemia, a multifactorial condition, may reflect B vitamin deficiency and is associated with increased risk of cardiovascular disease, thrombosis, and neurodegenerative and chronic gastrointestinal diseases in humans. Hyperhomocysteinemia has been reported in Greyhounds with suspected chronic enteropathy.
objectivesTo evaluate the frequencies of and the association between hypofolatemia and hyperhomocysteinemia in Greyhounds. ANIMALS: Data and serum samples from 559 Greyhounds.
methodsNested case-control study. The frequency of hypofolatemia in Greyhounds was determined by a laboratory database search. The relationship between hyperhomocysteinemia (measured by gas chromatography-mass spectrometry) and hypocobalaminemia and hypofolatemia was evaluated, and its frequency compared between healthy Greyhounds and Greyhounds with thrombosis or chronic diarrhea.
resultsHypofolatemia was identified in 172 of 423 (41%) Greyhounds and was more common in hypo- than in normocobalaminemic dogs (49% vs. 35%; P = .0064). Hyperhomocysteinemia was detected in 53 of 78 (68%) of Greyhounds, being more common in hypo- than in normofolatemic dogs (88% vs. 59%; P = .0175). All healthy Greyhounds, 21 of 30 (70%) of dogs with chronic diarrhea and 6 of 8 (75%) of those with thrombosis, were hyperhomocysteinemic. Serum HCY concentrations were inversely correlated with serum folate concentration (ρ = -0.28; P = .0386) and were positively associated with serum albumin concentration (ρ = 0.66; P = .0022). CONCLUSIONS AND CLINICAL RELEVANCE: Hyperhomocysteinemia occurs frequently in the Greyhound population. Its association with hypofolatemia suggests decreased intracellular availability of B vitamins, but the functional implications warrant further investigation. Hyperhomocysteinemia in Greyhounds potentially may serve as a spontaneous canine model to further investigate hyperhomocysteinemia in humans.
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