ArticleFolia microbiologica2017
Activity of novel inhibitors of Staphylococcus aureus biofilms.
Article in Folia microbiologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Interference of Celastrol with Cell Wall Synthesis and Biofilm Formation inAntibiotics (Basel, Switzerland) · 2025Article
- NLRP3 Inflammasomes: Dual Function in Infectious Diseases.Journal of immunology (Baltimore, Md. : 1950) · 2024Review
- Comparative evaluation of small molecules reported to be inhibitors ofMicrobiology spectrum · 2024Article
- Biology and Regulation of Staphylococcal Biofilm.International journal of molecular sciences · 2023Review
- Antibacterial Activity of an FtsZ Inhibitor Celastrol and Its Synergistic Effect with Vancomycin against EnterococciMicrobiology spectrum · 2023Article
- In vitro activity of celastrol in combination with thymol against carbapenem-resistant Klebsiella pneumoniae isolates.The Journal of antibiotics · 2022Article
- Sensitivity of Staphylococcal Biofilm to Selected Compounds of Plant Origin.Antibiotics (Basel, Switzerland) · 2021Review
- Biofilm Formation on Dental Implant Biomaterials byMaterials (Basel, Switzerland) · 2021Article
- Antimicrobial Activity and Mode of Action of Celastrol, a Nortriterpen Quinone Isolated from Natural Sources.Foods (Basel, Switzerland) · 2021Article
- Synergistic Activity of Equol and Meropenem against Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Effects of Tigecycline Combined with Azithromycin Against Biofilms of Multidrug-ResistantInfection and drug resistance · 2021Article
- Plant Derived Natural Products againstMolecules (Basel, Switzerland) · 2020Review
- Enhanced Antimicrobial Activity of N-Terminal Derivatives of a Novel Brevinin-1 Peptide from The Skin Secretion ofToxins · 2020Article
- Optimization of a High-Throughput 384-Well Plate-Based Screening Platform withInternational journal of molecular sciences · 2020Article
- The Antibacterial and Antibiofilm Activity of Telithromycin AgainstFrontiers in microbiology · 2020Article
- Anti-biofilm and Anti-Virulence Efficacy of Celastrol AgainstInternational journal of medical sciences · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus is one of the most important pathogens causing chronic biofilm infections. These are becoming more difficult to treat owing to drug resistance, particularly because S. aureus biofilms limit the efficacy of antimicrobial agents, leading to high morbidity and mortality. In the present study, we screened for inhibitors of S. aureus biofilm formation using a natural product library from the Korea Chemical Bank (KCB). Screening by crystal violet-based biomass staining assay identified hit compounds. Further examination of antibiofilm properties of these compounds was conducted and led to the identification of celastrol and telithromycin. In vitro, both celastrol and telithromycin were toxic to planktonic S. aureus and also active against a clinical methicillin-resistant S. aureus (MRSA) isolate. The effect of the compounds on preformed biofilms of clinical MRSA isolates was evaluated by confocal laser scanning microscopy (CLSM), which revealed the absence of typical biofilm architecture. In addition, celastrol and telithromycin inhibited the production of extracellular protein at selected sub-MIC concentrations, which revealed the reduced extracellular polymeric substance (EPS) secretion. Celastrol exhibited greater cytotoxicity than telithromycin. These data suggest that the hit compounds, especially telithromycin, could be considered novel inhibitors of S. aureus biofilm. Although the mechanisms of the effects on S. aureus biofilms are not fully understood, our data suggest that telithromycin could be a useful adjuvant therapeutic agent for S. aureus biofilm-related infections.
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