ArticleMolecular neurobiology2017
Myelin Genes and the Corpus Callosum: Proteolipid Protein 1 (PLP1) and Contactin 1 (CNTN1) Gene Variation Modulates Interhemispheric Integration.
Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05351411 (The Effect of Combined Progressive Functional Exercise on Contactin-1 and Contactin-2 Level in Mildly Disabled Persons With Multiple Sclerosis), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Combined Progressive Functional Exercise on Contactin-1 and Contactin-2 Level in Mildly Disabled Persons With Multiple Sclerosis: A Randomized Controlled Trial
Who cites it
4 citing papers in PubMed.
- Molecular and Cellular Substrates for the Friedreich Ataxia. Significance of Contactin Expression and of Antioxidant Administration.Molecules (Basel, Switzerland) · 2020Article
- Myelin Water Fraction Imaging Reveals Hemispheric Asymmetries in Human White Matter That Are Associated with Genetic Variation in PLP1.Molecular neurobiology · 2019Article
- PLP1 Gene Variation Modulates Leftward and Rightward Functional Hemispheric Asymmetries.Molecular neurobiology · 2018Article
- Mim-pong: a serious game for assessment and treatment of the lower limb in hemiparetic stroke patients.Archives of physiotherapyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Interhemispheric communication during demanding cognitive tasks shows pronounced interindividual variation. Differences in interhemispheric transfer time are constituted by the relative composition of slow and fast fibers. The speed of axonal conduction depends on the diameter of the axon and its myelination. To understand the possible genetic impact of myelin genes on performance in the Banich-Belger Task, a widely used paradigm to assess interhemispheric integration, 453 healthy adults were genotyped for 18 single nucleotide polymorphisms (SNPs) in six myelin-related candidate genes. We replicated the typical pattern of results in the Banich-Belger Task, supporting the idea that performance on cognitively demanding tasks is enhanced when cognitive processing is distributed across the two hemispheres. Moreover, allelic variations in the proteolipid protein 1 gene PLP1 and the contactin 1 gene CNTN1 correlated with the extent to which individual performance is enhanced by interhemispheric integration. Variation in myelin genes possibly affects the microstructure of the corpus callosum by altering oligodendrocyte structure. Therefore, these results provide a foundation for understanding how genetics plays a role in modulating the efficacy of transcallosal transmission.
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Registered trials
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