Evidence map›Paper›PMID 27864689›Full record

ArticleVirchows Archiv : an international journal of pathology2017

Epstein-Barr virus infection and gene promoter hypermethylation in rheumatoid arthritis patients with methotrexate-associated B cell lymphoproliferative disorders.

Kozue Ejima-Yamada, Yumi Oshiro, Seiichi Okamura, Tomoaki Fujisaki, Yasuhito Mihashi, Kazuo Tamura, Tomoko Fukushige, Masaru Kojima, Kazutoshi Shibuya, Morishige Takeshita

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Programmed cell death-ligand 1 (PD-L1)Clinical and experimental medicine · 2022
    Article
  6. Review
  7. Article
  8. Clinical management for other iatrogenic immunodeficiency-associated lymphoproliferative disorders.Journal of clinical and experimental hematopathology : JCEH · 2019
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Kozue Ejima-YamadaDivision of Medical Oncology, Hematology and Infectious Disease, Department of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
Yumi OshiroPathological Laboratory, Matsuyama Red Cross Hospital, 1 Bunkyo-cho, Matsuyama, 790-8524, Japan.
Seiichi OkamuraDepartment of Hematology, Clinical Research Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
Tomoaki FujisakiDepartment of Hematology, Matsuyama Red Cross Hospital, 1 Bunkyo-cho, Matsuyama, 790-8524, Japan.
Yasuhito MihashiDivision of Medical Oncology, Hematology and Infectious Disease, Department of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
Kazuo TamuraDivision of Medical Oncology, Hematology and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
Tomoko FukushigeDivision of Medical Oncology, Hematology and Infectious Disease, Department of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
Masaru KojimaDepartment of Pathology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-cho, Tochigi, 321-0293, Japan.
Kazutoshi ShibuyaDepartment of Pathology, Toho University Medical Center, Omori-nichi, Ota-ku, Tokyo, 143-8541, Japan.
Morishige TakeshitaDivision of Medical Oncology, Hematology and Infectious Disease, Department of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. m-take@adm.fukuoka-u.ac.jp.
Fukuoka University · JPMatsuyama Red Cross Hospital · JPDokkyo Medical University · JPNational Kyushu Medical Center · JPToho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We analyzed CpG-island hypermethylation status in 12 genes of paraffin-embedded tissues from 38 rheumatoid arthritis (RA) patients with methotrexate (MTX)-associated large B cell lymphoproliferative disorder (BLPD), 11 RA patients with non-MTX-associated BLPD (non-MTX-BLPD), 22 controls with diffuse large B cell lymphoma (DLBCL), and 10 controls with Epstein-Barr virus (EBV)

Indexed as

DNA MethylationAdultAgedAged, 80 and overAntirheumatic AgentsArthritis, RheumatoidCase-Control StudiesCpG IslandsEpstein-Barr Virus InfectionsFemaleGenetic MarkersHumansLymphoma, Large B-Cell, DiffuseLymphoproliferative DisordersMaleMethotrexateAntirheumatic AgentsGenetic MarkersMethotrexateB cell lymphoproliferative disorderCpG islandsDNA methylationEpstein–Barr virusMethotrexateRheumatoid arthritis

Identifiers

PMID27864689
OpenAlexW2557045302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.