Evidence map›Paper›PMID 27864663›Full record

ArticleIn vitro cellular & developmental biology. Animal2017

Mesenchymal stem cells attenuate hydrogen peroxide-induced oxidative stress and enhance neuroprotective effects in retinal ganglion cells.

Yi Cui, Nuo Xu, Wei Xu, Guoxing Xu

Erratum issuedAbstract read
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In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 50 citations in OpenAlex.

  1. Crosstalk between MSC-extracellular vesicles andFrontiers in pharmacology · 2025
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  5. Extracellular Vesicles Derived from Adipose-Derived Mesenchymal Stem Cells Alleviate Apoptosis and Oxidative Stress of Retinal Pigment Epithelial Cells Through Activation of Nrf2 Signaling Pathway.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Yi CuiDepartment of Ophthalmology, Fujian Medical University Union Hospital, No.29, Xinquan Road, Gulou District, Fuzhou, Fujian Province, 350001, China.
Nuo XuDepartment of Ophthalmology, Fujian Provincial Hospital, No.134, East Street, Gulou District, Fuzhou, Fujian Province, 350001, China.
Wei XuDepartment of Ophthalmology, Fujian Institute of Ophthalmology, The first Affiliated Hospital of Fujian Medical University, No.20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, 350005, China.
Guoxing XuDepartment of Ophthalmology, Fujian Institute of Ophthalmology, The first Affiliated Hospital of Fujian Medical University, No.20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, 350005, China. fjmuxuguoxing@126.com.
First Affiliated Hospital of Fujian Medical University · CNFujian Medical University · CNFujian Provincial Hospital · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The apoptosis of retinal ganglion cells leads to visual impairment and blindness in ocular neurodegenerative diseases, especially in diabetic retinopathy (DR). Mounting evidence suggests that oxidative stress contributes to the pathogenesis of DR. In the present study, we investigated whether bone mesenchymal stem cells (BMSCs) have protective ability to relieve hydrogen peroxide (H

Indexed as

Oxidative StressAnimalsApoptosisCell SurvivalCoculture TechniquesHydrogen PeroxideInflammationMesenchymal Stem CellsNerve Growth FactorsNeuroprotectionNeuroprotective AgentsRatsRetinal Ganglion CellsHydrogen PeroxideNerve Growth FactorsNeuroprotective AgentsHydrogen peroxideMesenchymal stem cellsProtective effectRetinal ganglion cells

Identifiers

PMID27864663
OpenAlexW4234733966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.