Evidence map›Paper›PMID 27864624›Full record

SynthesisInternational journal of clinical oncology2017

Sentinel lymph node biopsy using indocyanine green fluorescence in early-stage breast cancer: a meta-analysis.

Tomoharu Sugie, Takafumi Ikeda, Atsushi Kawaguchi, Akira Shimizu, Masakazu Toi

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in International journal of clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Tomoharu SugieDepartment Surgery, Kansai Medical University, Hirakata, Japan. sugiet@hirakata.kmu.ac.jp.
Takafumi IkedaInstitute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan.
Atsushi KawaguchiCenter for Comprehensive Community Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Akira ShimizuInstitute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan.
Masakazu ToiDepartment of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kyoto University Hospital · JPKansai Medical University · JPKyoto University · JPSaga University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sentinel lymph node (SLN) biopsy using indocyanine green (ICG) fluorescence is safe and has a high detection rate for SLNs. However, the results of this novel technique are heterogeneous. The objective of this meta-analysis was to evaluate the diagnostic performance of the ICG fluorescence method compared with the standard radioisotope (RI) method. All eligible studies were identified from 2005 through 2015. A proportion meta-analysis was performed using a fixed effects and/or random effects model based on the study heterogeneity. A total of 12 studies met the inclusion criteria and included 1736 women. There was no significant difference between ICG fluorescence and RI for SLN detection using either the fixed effects model [odds ratio (OR) 1.29, 95% confidence interval (CI) 0.87-1.90] or the random effects model (OR 1.32, 95% CI 0.54-3.18). There were seven studies reporting the detection rate for tumor-positive SLN. The ICG fluorescence method was significantly better than the RI method in the fixed effects model (OR 1.87, 95% CI 1.00-3.49) for staging axilla. However, there was no difference in the random effects model (OR 1.90, 95% CI 0.74-4.86). There was study outcome heterogeneity for the detection of SLN but not for tumor-positive SLN. There was no publication bias observed in the studies included. The ICG fluorescence method has valid diagnostic performance for SLN detection and shows a trend toward better axilla staging compared with the RI method. ICG fluorescence is a useful alternative to RI for SLN biopsy.

Indexed as

AxillaBreast NeoplasmsColoring AgentsFemaleFluorescenceHumansIndocyanine GreenLymphatic MetastasisLymph NodesSentinel Lymph NodeSentinel Lymph Node BiopsyColoring AgentsIndocyanine GreenBreast cancerFluorescenceIndocyanine greenRadioisotopeSentinel lymph node

Identifiers

PMID27864624
OpenAlexW2556311793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.