Evidence map›Paper›PMID 27864615›Full record

SynthesisIntensive care medicine2017

The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review.

Claire J Tipping, Meg Harrold, Anne Holland, Lorena Romero, Travis Nisbet, Carol L Hodgson

6 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 260 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
260citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03133377 phase3completednot on this mapstarted 2018, after this paper: background citation

A Prospective Multicentre Phase III Randomised Controlled Trial of Early Activity and Mobilisation Compared With Standard Care in Invasively Ventilated Patients in Intensive Care

TypeinterventionalSponsorAustralian and New Zealand Intensive Care Research CentreRan2018 to 2022Enrolled750ConditionsCritically Ill, Mechanically VentilatedArmsEarly activity and mobilisation
NCT04000997 completednot on this mapstarted 2019, after this paper: background citation

The Predictive Value of Cough Peak Flow for Extubation Success in Mechanically Ventilated Patients After Craniotomy: a Single-center Prospective Diagnostic Study

TypeobservationalSponsorBeijing Tiantan HospitalRan2019 to 2021Enrolled785ConditionsExtubation Success, Craniofacial Pain Syndrome, Cough Peak Flow, Endotracheal Tube
NCT05209763 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Standard vs Intensive Rehabilitation and Nutrition Regimen for Inpatients at the Intensive Care Unit

TypeinterventionalSponsorUniversity Hospital OstravaRan2022 to 2025Enrolled500ConditionsNutrition DisordersArmsMore intensive rehabilitation, More intensive nutrition
NCT07017517 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Physical Therapy on NLRP3 Inflammasome Activation and Muscle Atrophy in Critical Illness Myopathy (PT-NLRP3-CIM).

TypeinterventionalSponsorUniversity of ChileRan2026 to 2027Enrolled24ConditionsCritical Illness MyopathyArmsMotomed Letto® servo-assisted cycling + standard physiotherapy, Standard physiotherapy
NCT07093125 recruitingnot on this mapstarted 2025, after this paper: background citation

An Observational Study on Rehabilitation Practices in the ICU for Critically Ill Patients Undergoing Invasive Mechanical Ventilation - Report (REPOrt)

Typeobservational_patient_registrySponsorUniversita degli Studi di GenovaRan2025 to 2029Enrolled2,400ConditionsMechanical Ventilation, Pulmonary Rehabilitation, Intensive Care Units (ICUs), Quality of Life (QOL)
NCT07167121 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Etude de validité Predictive du Chelsea Critical Care Physical Assessment Tool (CPAx) Quant au Retour de l'Autonomie à la Marche 3 Mois après la Sortie de réanimation

Typeobservational_patient_registrySponsorCentre Hospitalier Intercommunal Elbeuf-Louviers-Val de ReuilRan2025 to 2026Enrolled25ConditionsICU Acquired Weakness, Intensive Care NeuropathyArmsCPAx
3 · Its place in the literature

Who cites it

260 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  18. Perceived barriers to early goal-directed mobility in the intensive care unit: Results of a quality improvement evaluation.Australian critical care : official journal of the Confederation of Australian Critical Care Nurses · 2022
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200 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Claire J TippingAustralian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Meg HarroldCurtin University, Perth, WA, Australia.
Anne HollandDepartment of Physiotherapy, The Alfred Hospital, Melbourne, VIC, Australia.
Lorena RomeroThe Alfred Hospital, Melbourne, VIC, Australia.
Travis NisbetFaculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
Carol L HodgsonAustralian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia. carol.hodgson@monash.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEarly active mobilisation and rehabilitation in the intensive care unit (ICU) is being used to prevent the long-term functional consequences of critical illness. This review aimed to determine the effect of active mobilisation and rehabilitation in the ICU on mortality, function, mobility, muscle strength, quality of life, days alive and out of hospital to 180 days, ICU and hospital lengths of stay, duration of mechanical ventilation and discharge destination, linking outcomes with the World Health Organization International Classification of Function Framework.

methodsA PRISMA checklist-guided systematic review and meta-analysis of randomised and controlled clinical trials.

resultsFourteen studies of varying quality including a total of 1753 patients were reviewed. Active mobilisation and rehabilitation had no impact on short- or long-term mortality (p > 0.05). Meta-analysis showed that active mobilisation and rehabilitation led to greater muscle strength (body function) at ICU discharge as measured using the Medical Research Council Sum Score (mean difference 8.62 points, 95% confidence interval (CI) 1.39-15.86), greater probability of walking without assistance (activity limitation) at hospital discharge (odds ratio 2.13, 95% CI 1.19-3.83), and more days alive and out of hospital to day 180 (participation restriction) (mean difference 9.69, 95% CI 1.7-17.66). There were no consistent effects on function, quality of life, ICU or hospital length of stay, duration of mechanical ventilation or discharge destination.

conclusionActive mobilisation and rehabilitation in the ICU has no impact on short- and long-term mortality, but may improve mobility status, muscle strength and days alive and out of hospital to 180 days. REGISTRATION OF PROTOCOL NUMBER: CRD42015029836.

Indexed as

Intensive Care UnitsCritical IllnessEarly AmbulationHospital MortalityHumansLength of StayMotor ActivityMuscle StrengthPatient DischargePhysical Therapy ModalitiesRespiration, ArtificialCritical illnessEarly mobilityIntensive care unitsMortalityRehabilitation

Identifiers

PMID27864615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.