ArticleMammalian genome : official journal of the International Mammalian Genome Society2017
Evaluation of the genetic basis of primary hypoadrenocorticism in Standard Poodles using SNP array genotyping and whole-genome sequencing.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Efficacy and side effects of long-term treatment strategies of canine primary hypoadrenocorticism.Frontiers in veterinary science · 2025Article
- A new future for dog breeding.Animal welfare (South Mimms, England) · 2025Review
- Comparison between typical primary and eunatraemic, eukalaemic hypoadrenocorticism: 92 cases.Irish veterinary journal · 2024Article
- The effect of inbreeding, body size and morphology on health in dog breeds.Canine medicine and genetics · 2021Article
- Comparison of sequencing data processing pipelines and application to underrepresented African human populations.BMC bioinformatics · 2021Article
- Genetic characterization of Addison's disease in Bearded Collies.BMC genomics · 2020Article
- Article
- Imputation of canine genotype array data using 365 whole-genome sequences improves power of genome-wide association studies.PLoS genetics · 2019Article
- Evaluation of a structured individualised protocol as a potential cost-effective diagnostic and therapeutic approach to chronic diarrhoea in the dog.Veterinary medicine and science · 2019Article
- DLA class II haplotypes show sex-specific associations with primary hypoadrenocorticism in Standard Poodle dogs.Immunogenetics · 2019Article
- A case-control survey study of environmental risk factors for primary hypoadrenocorticism in dogs.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Primary hypoadrenocorticism, also known as Addison's disease, is an autoimmune disorder leading to the destruction of the adrenal cortex and subsequent loss of glucocorticoid and mineralocorticoid hormones. The disease is prevalent in Standard Poodles and is believed to be highly heritable in the breed. Using genotypes derived from the Illumina Canine HD SNP array, we performed a genome-wide association study of 133 carefully phenotyped Standard Poodles (61 affected, 72 unaffected) and found no markers significantly associated with the disease. We also sequenced the entire genomes of 20 Standard Poodles (13 affected, 7 unaffected) and analyzed the data to identify common variants (including SNPs, indels, structural variants, and copy number variants) across affected dogs and variants segregating within a single pedigree of highly affected dogs. We identified several candidate genes that may be fixed in both Standard Poodles and a small population of dogs of related breeds. Further studies are required to confirm these findings more broadly, as well as additional gene-mapping efforts aimed at fully understanding the genetic basis of what is likely a complex inherited disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.