ArticleProceedings of the National Academy of Sciences of the United States of America2016
Proteomics and comparative genomics of Nitrososphaera viennensis reveal the core genome and adaptations of archaeal ammonia oxidizers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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99 citing papers in PubMed, 192 citations in OpenAlex.
- Oxygen production as an electron overflow pathway in ammonia-oxidizing archaea.Science advances · 2026Article
- Continental-scale integration of soil metagenomes and organic matter chemistry reveals ubiquitous microbial capacity for chemically-recalcitrant carbon decomposition.Nature communications · 2026Article
- Ammonia monooxygenase: a work in progress.Chemical science · 2026Review
- The potential of plant-derived triterpenoids as biological nitrification inhibitors.Applied microbiology and biotechnology · 2026Article
- Hypoosmolarity inhibits ammonia oxidation by terrestrial and freshwater Nitrosopumilaceae members.The ISME journal · 2026Article
- Oxygen production via nitric oxide dismutation in diverse ammonia oxidizers.ISME communications · 2026Article
- Metabolic potential and contributions of ammonia-oxidizing microorganisms and complete ammonia oxidizers to soil nitrification in upland soils of northern China.ISME communications · 2026Article
- Targeted assembly recovers high ammonia monooxygenase diversity in mudflat intertides.mSystems · 2025Article
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- Exploring proteinmBio · 2025Article
- Genomic profiling of soil nitrifying microorganisms enriched on floating membrane filter.Journal of microbiology (Seoul, Korea) · 2025Article
- Nitrous oxide production via enzymatic nitroxyl from the nitrifying archaeonProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Biofilm lifestyle across different lineages of ammonia-oxidizing archaea.The ISME journal · 2025Article
- Predicting gene distribution in ammonia-oxidizing archaea using phylogenetic signals.ISME communications · 2025Article
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- Microbial diversity and biogeochemical interactions in the seismically active and COEnvironmental microbiome · 2024Article
- Adaptive traits ofmBio · 2024Article
- Microbial Ecology of Granular Biofilm Technologies for Wastewater Treatment: A Review.Microorganisms · 2024Review
- Novel order-level lineage of ammonia-oxidizing archaea widespread in marine and terrestrial environments.The ISME journal · 2024Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ammonia-oxidizing archaea (AOA) are among the most abundant microorganisms and key players in the global nitrogen and carbon cycles. They share a common energy metabolism but represent a heterogeneous group with respect to their environmental distribution and adaptions, growth requirements, and genome contents. We report here the genome and proteome of Nitrososphaera viennensis EN76, the type species of the archaeal class Nitrososphaeria of the phylum Thaumarchaeota encompassing all known AOA. N. viennensis is a soil organism with a 2.52-Mb genome and 3,123 predicted protein-coding genes. Proteomic analysis revealed that nearly 50% of the predicted genes were translated under standard laboratory growth conditions. Comparison with genomes of closely related species of the predominantly terrestrial Nitrososphaerales as well as the more streamlined marine Nitrosopumilales [Candidatus (Ca.) order] and the acidophile "Ca. Nitrosotalea devanaterra" revealed a core genome of AOA comprising 860 genes, which allowed for the reconstruction of central metabolic pathways common to all known AOA and expressed in the N. viennensis and "Ca Nitrosopelagicus brevis" proteomes. Concomitantly, we were able to identify candidate proteins for as yet unidentified crucial steps in central metabolisms. In addition to unraveling aspects of core AOA metabolism, we identified specific metabolic innovations associated with the Nitrososphaerales mediating growth and survival in the soil milieu, including the capacity for biofilm formation, cell surface modifications and cell adhesion, and carbohydrate conversions as well as detoxification of aromatic compounds and drugs.
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