ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017
Loss of scleraxis in mice leads to geometric and structural changes in cortical bone, as well as asymmetry in fracture healing.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Injectable Cell-Laden Nanofibrous Matrix for Treating Annulus Fibrosus Defects in Porcine Model: An Organ Culture Study.Life (Basel, Switzerland) · 2022Article
- Influence of microcurrent on the modulation of remodelling genes in a wound healing assay.Molecular biology reports · 2021Article
- Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Impact of Uniaxial Stretching on Both Gliding and Traction Areas of Tendon Explants in a Novel Bioreactor.International journal of molecular sciences · 2020Article
- Cardiac Fibroblast to Myofibroblast Phenotype Conversion-An Unexploited Therapeutic Target.Journal of cardiovascular development and disease · 2019Review
- Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Tendon healing in the context of complex fractures.Clinical reviews in bone and mineral metabolism · 2018Article
- Transcriptional Mechanisms of Secondary Fracture Healing.Current osteoporosis reports · 2018Review
- Time-series expression profile analysis of fracture healing in young and old mice.Molecular medicine reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Scleraxis (Scx) is a known regulator of tendon development, and recent work has identified the role of Scx in bone modeling. However, the role of Scx in fracture healing has not yet been explored. This study was conducted to identify the role of Scx in cortical bone development and fracture healing. Scx green fluorescent protein-labeled (ScxGFP) reporter and Scx-knockout (Scx-mutant) mice were used to assess bone morphometry and the effects of fracture healing on Scx localization and gene expression, as well as callus healing response. Botulinum toxin (BTX) was used to investigate muscle unloading effects on callus shape. Scx-mutant long bones had structural and mechanical defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.