Evidence map›Paper›PMID 27864348›Full record

ArticleCancer research2016

Systems Approaches to Cancer Biology.

Tenley C Archer, Elana J Fertig, Sara J C Gosline, Marc Hafner, Shannon K Hughes, Brian A Joughin, Aaron S Meyer, Stephen R Piccolo, Ayesha N Shajahan-Haq

Abstract read
In one paragraph

Article in Cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
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  4. Article
  5. Article
  6. Review
  7. Review
  8. Identification ofCell journal · 2021
    Article
  9. Review
  10. Review
  11. Article
  12. Classification of Widely and Rarely Expressed Genes with Recurrent Neural Network.Computational and structural biotechnology journal · 2019
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tenley C ArcherDepartment of Neurology, Boston Children's Hospital, Boston, Massachusetts.
Elana J FertigSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.
Sara J C GoslineSage Bionetworks, Seattle, Washington.
Marc HafnerDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts.
Shannon K HughesDivision of Cancer Biology, National Cancer Institute of the NIH, Rockville, Maryland.
Brian A JoughinKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Aaron S MeyerKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. ameyer@asmlab.org.
Stephen R PiccoloDepartment of Biology, Brigham Young University, Provo, Utah.
Ayesha N Shajahan-HaqLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia.

Funding

Optimizing Targeted Breast Cancer Therapy by Mathematical Modeling and Experimental StudiesR01CA201092 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI BAUMANN, WILLIAM THOMAS, SHAJAHAN-HAQ, AYESHA N. · 2016 to 2020
$2.0M
Adapter-Layer RTK Signaling: Basic Understanding & Targeted DrugResistanceDP5OD019815 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MEYER, AARON SAMUEL · 2014 to 2018
$2.0M
Dynamical Models of Cetuximab Resistance in HNSCC Based on Serial Genomics DataR01CA177669 · NCI · JOHNS HOPKINS UNIVERSITY · PI FERTIG, ELANA · 2014 to 2019
$1.8M
NCI NIH HHS R01 CA177669NCI NIH HHS R01 CA201092NIH HHS DP5 OD019815
6 · The paper itself

Abstract

Cancer systems biology aims to understand cancer as an integrated system of genes, proteins, networks, and interactions rather than an entity of isolated molecular and cellular components. The inaugural Systems Approaches to Cancer Biology Conference, cosponsored by the Association of Early Career Cancer Systems Biologists and the National Cancer Institute of the NIH, focused on the interdisciplinary field of cancer systems biology and the challenging cancer questions that are best addressed through the combination of experimental and computational analyses. Attendees found that elucidating the many molecular features of cancer inevitably reveals new forms of complexity and concluded that ensuring the reproducibility and impact of cancer systems biology studies will require widespread method and data sharing and, ultimately, the translation of important findings to the clinic. Cancer Res; 76(23); 6774-7. ©2016 AACR.

Indexed as

NeoplasmsHumansSystems Biology

Identifiers

PMID27864348
PMCPMC5135591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.