Evidence map›Paper›PMID 27864286›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

Transforming growth factor-β plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma.

Kazuyuki Tsujino, Nilgun Isik Reed, Amha Atakilit, Xin Ren, Dean Sheppard

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. FAPI TracerPharmaceuticals (Basel, Switzerland) · 2025
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  4. Intrapulmonary T Cells Are Sufficient forInternational journal of molecular sciences · 2024
    Article
  5. Article
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  7. Role of Fra-2 in cancer.Cell death and differentiation · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Fra-2-expressing macrophages promote lung fibrosis in mice.The Journal of clinical investigation · 2019
    Article
  12. Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans.The Journal of clinical endocrinology and metabolism · 2018
    Article
  13. Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease.Matrix biology : journal of the International Society for Matrix Biology · 2018
    Review
  14. Article
  15. Review
  16. Article
  17. Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function.American journal of physiology. Lung cellular and molecular physiology · 2017
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kazuyuki TsujinoDepartment of Medicine, University of California, San Francisco, California.
Nilgun Isik ReedDepartment of Medicine, University of California, San Francisco, California.
Amha AtakilitDepartment of Medicine, University of California, San Francisco, California.
Xin RenDepartment of Medicine, University of California, San Francisco, California.
Dean SheppardDepartment of Medicine, University of California, San Francisco, California dean.sheppard@ucsf.edu.
University of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy and feasibility of targeting transforming growth factor-β (TGFβ) in pulmonary fibrosis and lung vascular remodeling in systemic sclerosis (SSc) have not been well elucidated. In this study we analyzed how blocking TGFβ signaling affects pulmonary abnormalities in Fos-related antigen 2 (Fra-2) transgenic (Tg) mice, a murine model that manifests three important lung pathological features of SSc: fibrosis, inflammation, and vascular remodeling. To interrupt TGFβ signaling in the Fra-2 Tg mice, we used a pan-TGFβ-blocking antibody, 1D11, and Tg mice in which TGFβ receptor type 2 (Tgfbr2) is deleted from smooth muscle cells and myofibroblasts (α-SMA-Cre

Indexed as

ActinsAnimalsBone Morphogenetic Protein Receptors, Type IIDisease Models, AnimalFos-Related Antigen-2Gene DeletionGranulocytesMice, TransgenicMyocytes, Smooth MusclePneumoniaProtein Serine-Threonine KinasesPulmonary AlveoliPulmonary FibrosisReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IIScleroderma, SystemicActa2 protein, mouseActinsBone Morphogenetic Protein Receptors, Type IIFosl2 protein, mouseFos-Related Antigen-2Protein Serine-Threonine KinasesReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IITransforming Growth Factor betafibrosisinflammationsystemic sclerosistransforming growth factor-βvasculopathy

Identifiers

PMID27864286
PMCPMC5283926
OpenAlexW2549606010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.