Evidence map›Paper›PMID 27864284›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

Region-specific role for Pten in maintenance of epithelial phenotype and integrity.

Per Flodby, Janice M Liebler, Mitsuhiro Sunohara, Dan R Castillo, Alicia M McConnell, Manda S Krishnaveni, Agnes Banfalvi, Min Li, Barry Stripp, Beiyun Zhou and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Hyaluronan Directs Alveolar Type II Cell Response to Acute Ozone Exposure in Mice.American journal of respiratory cell and molecular biology · 2025
    Article
  4. Article
  5. PTEN Inhibition in Human Disease Therapy.Molecules (Basel, Switzerland) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Per FlodbyWill Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Janice M LieblerWill Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0002-4166-6197
Mitsuhiro SunoharaWill Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Dan R CastilloWill Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Alicia M McConnellDepartments of Medicine and Biomedical Sciences, Lung and Regenerative Medicine Institutes, Cedars-Sinai Medical Center, Los Angeles, California.
Manda S KrishnaveniWill Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Agnes BanfalviWill Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Min LiDivision of Neonatalogy, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California.
Barry StrippDepartments of Medicine and Biomedical Sciences, Lung and Regenerative Medicine Institutes, Cedars-Sinai Medical Center, Los Angeles, California.
Beiyun ZhouWill Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Edward D CrandallWill Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Parviz MinooDivision of Neonatalogy, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California.
Zea BorokWill Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; zborok@med.usc.edu.
University of Southern California · USCedars-Sinai Medical Center · US

Funding

USC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OOKHTENS, MURAD · 1995 to 2020
$21.8M
MAPGen Knowledge Base (MAPGenKB) and Coordination CenterU01HL108634 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHOU, XIANGHONG JASMINE · 2011 to 2015
$5.3M
Role of Chaperone GRP78 and Mitochondrial Dysfunction in ER Stress-Mediated Pulmonary FibrosisR01HL114959 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANN, DAVID K., ZHOU, BEIYUN · 2013 to 2025
$4.2M
Mechanisms of Lung Development and InjuryR01HL095349 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MINOO, PARVIZ MINOO · 2009 to 2017
$3.6M
THE BIOLOGY OF PULMONARY ALVEOLAR FORMATIONR01HL122764 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MINOO, PARVIZ MINOO · 2015 to 2018
$1.6M
Confocal Microscopy Imaging SystemS10RR022508 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OOKHTENS, MURAD · 2007 to 2007
$415k
NCRR NIH HHS S10 RR022508NHLBI NIH HHS R01 HL095349NHLBI NIH HHS R01 HL114959NHLBI NIH HHS R01 HL122764NHLBI NIH HHS U01 HL108634NIDDK NIH HHS P30 DK048522
6 · The paper itself

Abstract

Previous studies have demonstrated resistance to naphthalene-induced injury in proximal airways of mice with lung epithelial-specific deletion of the tumor-suppressor gene Pten, attributed to increased proliferation of airway progenitors. We tested effects of Pten loss following bleomycin injury, a model typically used to study distal lung epithelial injury, in conditional Pten

Indexed as

Organ SpecificityAnimalsApoptosisBiomarkersBleomycinCadherinsComplianceEpithelial CellsGene Expression RegulationHyperplasiaInflammationIn Situ Nick-End LabelingIntegrasesIntercellular JunctionsLungLung InjuryBiomarkersBleomycinCadherinsCre recombinaseIntegrasesPTEN PhosphohydrolaseRNA, MessengerSod3 protein, mouseSuperoxide Dismutaseadherens junctionsalveolar epitheliumbleomycincell adhesionreactive oxygen species

Identifiers

PMID27864284
PMCPMC5283927
OpenAlexW2553329539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.