Evidence map›Paper›PMID 27864202›Full record

ReviewAmerican journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists2016

Implementation of inpatient models of pharmacogenetics programs.

Larisa H Cavallari, Craig R Lee, Julio D Duarte, Edith A Nutescu, Kristin W Weitzel, George A Stouffer, Julie A Johnson

Abstract readReview
In one paragraph

Review in American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Observational
  3. Review
  4. Pharmacogenetics: Opportunities for theAnnual review of pharmacology and toxicology · 2025
    Review
  5. Receptor Pharmacogenomics: Deciphering Genetic Influence on Drug Response.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Approaches to assessing the provider experience with clinical pharmacogenomic information: a scoping review.Genetics in medicine : official journal of the American College of Medical Genetics · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Precision Pharmacotherapy: Integrating Pharmacogenomics into Clinical Pharmacy Practice.Journal of the American College of Clinical Pharmacy : JACCP · 2019
    Article
  19. Current practices in the delivery of pharmacogenomics: Impact of the recommendations of the Pharmacy Practice Model Summit.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Larisa H CavallariDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL. lcavallari@cop.ufl.edu.
Craig R LeeDivision of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC.
Julio D DuarteDepartment of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL.
Edith A NutescuDepartment of Pharmacy Systems, Outcomes and Policy, University of Illinois at Chicago, Chicago, IL.
Kristin W WeitzelDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL.
George A StoufferDivision of Cardiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Julie A JohnsonDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL.

Funding

Sparking Advancements in Genomic MedicineU01HG007269 · NHGRI · UNIVERSITY OF FLORIDA · PI CAVALLARI, LARISA HUMMA, JOHNSON, JULIE A. · 2013 to 2024
$17.0M
Improving treatment personalization for pulmonary hypertension associated with diastolic heart failureK23GM112014 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUARTE, JULIO DAVID · 2015 to 2018
$711k
Patient-Centered Anticoagulation Self-Monitoring in Minority Patients.K23HL112908 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI NUTESCU, EDITH · 2013 to 2016
$524k
NHGRI NIH HHS U01 HG007269NHLBI NIH HHS K23 HL112908NIGMS NIH HHS K23 GM112014
6 · The paper itself

Abstract

purposeThe operational elements essential for establishing an inpatient pharmacogenetic service are reviewed, and the role of the pharmacist in the provision of genotype-guided drug therapy in pharmacogenetics programs at three institutions is highlighted. SUMMARY: Pharmacists are well positioned to assume important roles in facilitating the clinical use of genetic information to optimize drug therapy given their expertise in clinical pharmacology and therapeutics. Pharmacists have assumed important roles in implementing inpatient pharmacogenetics programs. This includes programs designed to incorporate genetic test results to optimize antiplatelet drug selection after percutaneous coronary intervention and personalize warfarin dosing. Pharmacist involvement occurs on many levels, including championing and leading pharmacogenetics implementation efforts, establishing clinical processes to support genotype-guided therapy, assisting the clinical staff with interpreting genetic test results and applying them to prescribing decisions, and educating other healthcare providers and patients on genomic medicine. The three inpatient pharmacogenetics programs described use reactive versus preemptive genotyping, the most feasible approach under the current third-party payment structure. All three sites also follow Clinical Pharmacogenetics Implementation Consortium guidelines for drug therapy recommendations based on genetic test results.

conclusionWith the clinical emergence of pharmacogenetics into the inpatient setting, it is important that pharmacists caring for hospitalized patients are well prepared to serve as experts in interpreting and applying genetic test results to guide drug therapy decisions. Since genetic test results may not be available until after patient discharge, pharmacists practicing in the ambulatory care setting should also be prepared to assist with genotype-guided drug therapy as part of transitions in care.

Indexed as

Professional RoleProgram DevelopmentGenotypeHospitalizationHumansPatient Care TeamPharmacogeneticsPharmacy Service, Hospitalclopidogrelgenotypeinpatientpharmacistspharmacogeneticswarfarin

Identifiers

PMID27864202
PMCPMC5359627

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.