Evidence map›Paper›PMID 27864084›Full record

ReviewSeminars in cell & developmental biology2017

Development and regeneration of vestibular hair cells in mammals.

Joseph C Burns, Jennifer S Stone

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 122 citations in OpenAlex.

  1. Article
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  8. Article
  9. Review
  10. Article
  11. Article
  12. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. bioRxiv : the preprint server for biology · 2024
    Article
  17. Modern In Vitro Techniques for Modeling Hearing Loss.Bioengineering (Basel, Switzerland) · 2024
    Review
  18. Article
  19. A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2Journal of the Association for Research in Otolaryngology : JARO · 2024
    Article
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joseph C BurnsDecibel Therapeutics, 215 First St., Suite 430, Cambridge, MA 02142, USA. Electronic address: jburns@decibeltx.com.
Jennifer S StoneDepartment of Otolaryngology/Head and Neck Surgery and The Virginia Merrill Bloedel Hearing Research Center, University of Washington School of Medicine, Box 357923, Seattle, WA 98195-7923, USA. Electronic address: stoner@uw.edu.
University of Washington · US

Funding

Vestibular hair cell turnover in normal adult mammalsR01DC013771 · NIDCD · UNIVERSITY OF WASHINGTON · PI STONE, JENNIFER S. · 2014 to 2023
$5.1M
Structure-function analyses on novel processes of type II vestibular hair cellsR21DC013358 · NIDCD · UNIVERSITY OF WASHINGTON · PI EATOCK, RUTH ANNE, STONE, JENNIFER S. · 2013 to 2014
$451k
Replacement of vestibular hair cells in normal and damaged adult miceF32DC013695 · NIDCD · UNIVERSITY OF WASHINGTON · PI FURRER BUCKS, STEPHANIE ANN · 2013 to 2014
$102k
NIDCD NIH HHS F32 DC013695NIDCD NIH HHS R01 DC013771NIDCD NIH HHS R21 DC013358
6 · The paper itself

Abstract

Vestibular sensation is essential for gaze stabilization, balance, and perception of gravity. The vestibular receptors in mammals, Type I and Type II hair cells, are located in five small organs in the inner ear. Damage to hair cells and their innervating neurons can cause crippling symptoms such as vertigo, visual field oscillation, and imbalance. In adult rodents, some Type II hair cells are regenerated and become re-innervated after damage, presenting opportunities for restoring vestibular function after hair cell damage. This article reviews features of vestibular sensory cells in mammals, including their basic properties, how they develop, and how they are replaced after damage. We discuss molecules that control vestibular hair cell regeneration and highlight areas in which our understanding of development and regeneration needs to be deepened.

Indexed as

Animalsbeta CateninCell DifferentiationCell LineageCell ProliferationCyclin-Dependent Kinase Inhibitor p19Cyclin-Dependent Kinase Inhibitor p21Gene Expression Regulation, DevelopmentalGravity SensingHair Cells, AuditoryHair Cells, VestibularMiceOrganogenesisPostural BalanceRegenerationSignal Transductionbeta CateninCdkn1a protein, mouseCdkn2d protein, mouseCTNNB1 protein, mouseCyclin-Dependent Kinase Inhibitor p19Cyclin-Dependent Kinase Inhibitor p21DevelopmentHair cellRegenerationSupporting cellVestibular

Identifiers

PMID27864084
PMCPMC5423856
OpenAlexW2553319993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.