ArticleNeuroImage2017
Alterations of resting state functional network connectivity in the brain of nicotine and alcohol users.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Functional Connectivity Disruptions in Grey Matter Volume-Altered Brain Regions Among Male Smokers: A Neuroimaging Study.Addiction biology · 2025Pooled it
- Relating Functional Connectivity and Alcohol Use Disorder: A Systematic Review and Derivation of Relevance Maps for Regions and Connections.Human brain mapping · 2025Pooled it
- Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder.Scientific reports · 2021Pooled it
- Trial
- Repetitive deep TMS in alcohol dependent patients halts progression of white matter changes in early abstinence.Psychiatry and clinical neurosciences · 2024Trial
- The effects of nalmefene on the impulsive and reflective system in alcohol use disorder: A resting-state fMRI study.Psychopharmacology · 2022Trial
- Correlations Between the DMN and the Smoking Cessation Outcome of a Real-Time fMRI Neurofeedback Supported Exploratory Therapy Approach: Descriptive Statistics on Tobacco-Dependent Patients.Clinical EEG and neuroscience · 2022Trial
- Drinking reduction during cognitive behavioral therapy for alcohol use disorder is associated with a reduction in anterior insula-bed nucleus of the stria terminalis resting-state functional connectivity.Alcoholism, clinical and experimental research · 2021Trial
- The Default Mode Network and Behavior: a Model to Analyse Psycho-Physiological Interactions in Resting State fMRI.Brain topography · 2026Article
- Chronic ethanol exposure reduces resting state functional connectivity and regional synchrony in male rats.Psychopharmacology · 2026Article
- Reduced Whole-Brain Network Segregation and Dorsal Anterior-Cingulate Cortex Neurochemical Alterations in Chronic Smokers.Brain and behavior · 2026Article
- Elevated intron retention implicates neuroinflammation in brains of individuals with alcohol use disorder.Brain communications · 2026Article
- Neural correlates of altered loss aversion in alcohol use disorder: preliminary evidence of sex-related differences from 18F-FDG-PET imaging.Frontiers in psychiatry · 2026Article
- Abstinence Alters Triple Network Dynamics in Moderate-to-Heavy Drinkers.Human brain mapping · 2025Article
- Effects of alcohol and cannabis co-use on salience network resting state functional connectivity in individuals who drink alcohol heavily.Drug and alcohol dependence · 2025Article
- Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder.Frontiers in psychiatry · 2025Article
- Connectivity Changes Following Episodic Future Thinking in Alcohol Use Disorder.Brain connectivity · 2024Article
- Relationship of interoceptive accuracy in acne vulgaris patients: A prospective, controlled study.Archives of dermatological research · 2024Article
- Greater ventral striatal functional connectivity in cigarette smokers relative to non-smokers across a spectrum of alcohol consumption.Brain imaging and behavior · 2024Article
- Atypical effective connectivity from the frontal cortex to striatum in alcohol use disorder.Translational psychiatry · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Alcohol and nicotine intake result in neurological alterations at the circuit level. Resting state functional connectivity has shown great potential in identifying these alterations. However, current studies focus on specific seeds and leave out many brain regions where effects might exist. The present study uses a data driven technique for brain segmentation covering the whole brain. Functional magnetic-resonance-imaging (fMRI) data were collected from 188 subjects:51 non-substance consumption controls (CTR), 36 smoking-and-drinking subjects (SAD), 28 drinkers (DRN), and 73 smokers (SMK). Data were processed using group independent component analysis to derive resting state networks (RSN). The resting state functional network connectivity (rsFNC) was then calculated through correlation between time courses. One-way ANOVA tests were used to detect rsFNC differences among the four groups. A total of 50 ANOVA tests were significant after multi-comparison correction. Results delineate a general pattern of hypo-connectivity in the substance consumers. Precuneus, postcentral gyrus, insula and visual cortex were the main brain areas with rsFNC reduction suggesting reduced interoceptive awareness in drinkers. In addition, connectivity reduction between postcentral and one RSN covering right fusiform and lingual gyri showed significant association with severity of hazardous drinking. In smokers, connectivity changes agreed with the idea of a shift towards endogenous information processing, represented by the DMN. Hypo-connectivity between thalamus and putamen was observed in smokers. In contrast, the angular gyrus showed hyper-connectivity with the precuneus linked to smoking and significantly correlated with nicotine dependence severity. In spite of the presence of common effects, our results suggest that particular effects of alcohol and nicotine can be separated and identified. Results also suggest that concurrent use of both substances affects brain connectivity in a complex manner, requiring careful consideration of interaction effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.