Evidence map›Paper›PMID 27863967›Full record

ReviewVirus research2017

Host cell restriction factors that limit transcription and replication of human papillomavirus.

Samuel S Porter, Wesley H Stepp, James D Stamos, Alison A McBride

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Virus research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Role of HPV16 E1 in cervical carcinogenesis.Frontiers in cellular and infection microbiology · 2022
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Samuel S PorterLaboratory of Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 33 North Drive, MSC3209, Bethesda, MD 20892, USA; Biological Sciences Graduate Program, University of Maryland, University of Maryland, 4066 Campus Drive, College Park, MD 20742, USA.
Wesley H SteppLaboratory of Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 33 North Drive, MSC3209, Bethesda, MD 20892, USA.
James D StamosLaboratory of Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 33 North Drive, MSC3209, Bethesda, MD 20892, USA.
Alison A McBrideLaboratory of Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 33 North Drive, MSC3209, Bethesda, MD 20892, USA. Electronic address: amcbride@nih.gov.
National Institute of Allergy and Infectious Diseases · USNational Institutes of Health · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008719 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI, DESHMUKH, MOHANISH P · 1999 to 2023
$15.1M
Replication mechanisms of human papillomaviruses (HPV)ZIAAI000713 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MCBRIDE, ALISON · 2009 to 2025
$12.4M
HPV Elements Required for Alpha HPV Genome Replication and PartitioningZIAAI001073 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MCBRIDE, ALISON · 2009 to 2017
$2.7M
Characterization: Papillomavirus Regulatory ProteinsZ01AI000713 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI MCBRIDE, ALISON · 1994 to 2008
$1.4M
Graduate Training in VirologyT32AI125186 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI SIMON, ANNE ELIZABETH · 2016 to 2020
$1.3M
Intramural NIH HHS Z01 AI000713NIAID NIH HHS T32 AI125186NIGMS NIH HHS T32 GM008719
6 · The paper itself

Abstract

The life cycle of human papillomaviruses (HPV) is tightly regulated by the differentiation state of mucosal and cutaneous keratinocytes. To counteract viral infection, constitutively expressed cellular factors, which are defined herein as restriction factors, directly mitigate viral gene expression and replication. In turn, some HPV gene products target these restriction factors and abrogate their anti-viral effects to establish efficient gene expression and replication programs. Ironically, in certain circumstances, this delicate counterbalance between viral gene products and restriction factors facilitates persistent infection by HPVs. This review serves to recapitulate the current knowledge of nuclear restriction factors that directly affect the HPV infectious cycle.

Indexed as

Genome, ViralHost-Pathogen InteractionsAdaptor Proteins, Signal TransducingAntigens, NuclearAutoantigensCell DifferentiationChromatinCo-Repressor ProteinsGene Expression RegulationHumansKeratinocytesMolecular ChaperonesNuclear ProteinsPapillomaviridaePapillomavirus InfectionsPromyelocytic Leukemia ProteinAdaptor Proteins, Signal TransducingAntigens, NuclearAutoantigensChromatinCo-Repressor ProteinsDAXX protein, humanMolecular ChaperonesNuclear ProteinsPML protein, humanPromyelocytic Leukemia ProteinSP100 protein, humanViral ProteinsHPVIFI16IFIT1Intrinsic immunityRestriction factorSp100

Identifiers

PMID27863967
PMCPMC5325803
OpenAlexW2552891626

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.