Evidence map›Paper›PMID 27863955›Full record

ArticleCell systems2016

The BLUEPRINT Data Analysis Portal.

José María Fernández, Victor de la Torre, David Richardson, Romina Royo, Montserrat Puiggròs, Valentí Moncunill, Stamatina Fragkogianni, Laura Clarke, BLUEPRINT Consortium, Paul Flicek and 4 more

Abstract read
In one paragraph

Article in Cell systems, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation.Proceedings of the National Academy of Sciences of the United States of America · 2026
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

José María FernándezStructural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain; Spanish Bioinformatics Institute INB-ISCIII ES-ELIXIR, Madrid 28029, Spain.
Victor de la TorreStructural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain; Spanish Bioinformatics Institute INB-ISCIII ES-ELIXIR, Madrid 28029, Spain.
David RichardsonEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Romina RoyoSpanish Bioinformatics Institute INB-ISCIII ES-ELIXIR, Madrid 28029, Spain; Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB, Research Program in Computational Biology, BSC - CRG - IRB, Barcelona 08028, Spain.
Montserrat PuiggròsBarcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB, Research Program in Computational Biology, BSC - CRG - IRB, Barcelona 08028, Spain.
Valentí MoncunillBarcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB, Research Program in Computational Biology, BSC - CRG - IRB, Barcelona 08028, Spain.
Stamatina FragkogianniBarcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB, Research Program in Computational Biology, BSC - CRG - IRB, Barcelona 08028, Spain.
Laura ClarkeEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
BLUEPRINT Consortiumhttp://www.blueprint-epigenome.eu/.
Paul FlicekEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Daniel RicoStructural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
David TorrentsBarcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB, Research Program in Computational Biology, BSC - CRG - IRB, Barcelona 08028, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain.
Enrique Carrillo de Santa PauStructural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address: ecarrillo@cnio.es.
Alfonso ValenciaStructural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain; Spanish Bioinformatics Institute INB-ISCIII ES-ELIXIR, Madrid 28029, Spain. Electronic address: valencia@cnio.es.

Funding

Wellcome Trust 108749
6 · The paper itself

Abstract

The impact of large and complex epigenomic datasets on biological insights or clinical applications is limited by the lack of accessibility by easy, intuitive, and fast tools. Here, we describe an epigenomics comparative cyber-infrastructure (EPICO), an open-access reference set of libraries to develop comparative epigenomic data portals. Using EPICO, large epigenome projects can make available their rich datasets to the community without requiring specific technical skills. As a first instance of EPICO, we implemented the BLUEPRINT Data Analysis Portal (BDAP). BDAP provides a desktop for the comparative analysis of epigenomes of hematopoietic cell types based on results, such as the position of epigenetic features, from basic analysis pipelines. The BDAP interface facilitates interactive exploration of genomic regions, genes, and pathways in the context of differentiation of hematopoietic lineages. This work represents initial steps toward broadly accessible integrative analysis of epigenomic data across international consortia. EPICO can be accessed at https://github.com/inab, and BDAP can be accessed at http://blueprint-data.bsc.es.

Indexed as

EpigenomicsCell DifferentiationEpigenesis, GeneticGenomeInternetSoftwareUser-Computer InterfacebioinformaticsBLUEPRINT Data Analysis PortalBLUEPRINT epigenomescyber-infrastructureepigenomic data mining toolsepigenomic data visualizationepigenomicshematopoiesisInternational Human Epigenomes Consortiumleukemia

Identifiers

PMID27863955
PMCPMC5919098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.