Evidence map›Paper›PMID 27863901›Full record

SynthesisSleep medicine reviews2017

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015.

Lama M Chahine, Amy W Amara, Aleksandar Videnovic

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Sleep medicine reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 8 pooled it
17.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 8 syntheses or guidelines pooled it, 326 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Psychological outcomes of the COVID-19 pandemic in patients with Parkinson's disease: A systematic review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2022
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Diagnostic accuracy of REM sleep behaviour disorder screening questionnaire: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
    Pooled it
  9. Trial
  10. ENLITE PD: A Randomized Clinical Trial of Light Therapy for Impaired Sleep in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Trial
  11. Trial
  12. Trial
  13. Trial
  14. Sleep macro-architecture in patients with Parkinson's disease does not change during the first night of neurostimulation in a pilot study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Trial
  15. Solriamfetol for Excessive Daytime Sleepiness in Parkinson's Disease: Phase 2 Proof-of-Concept Trial.Movement disorders : official journal of the Movement Disorder Society · 2021
    Trial
  16. Randomized, Controlled Trial of Exercise on Objective and Subjective Sleep in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020
    Trial
  17. Trial
  18. Article
  19. Article
  20. Article

112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Lama M ChahineParkinson's Disease and Movement Disorders Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 330 S. 9th st, Philadelphia, PA 19107, USA. Electronic address: lamachahine@hotmail.com.
Amy W AmaraDivision of Movement Disorders, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Aleksandar VidenovicNeurobiological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Harvard University · USUniversity of Alabama at Birmingham · USUniversity of Pennsylvania · US

Funding

Project IV: "Alpha-Synuclein Strains & Diverse Synucleinopathies"P50NS053488 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2007 to 2017
$20.9M
Circadian Rhythms and Sleep-Wake Cycles in Parkinson's DiseaseK23NS072283 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VIDENOVIC, ALEKSANDAR · 2012 to 2017
$935k
The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD PatientsK23NS080912 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMARA, AMY WILLIS · 2012 to 2016
$934k
NINDS NIH HHS K23 NS072283NINDS NIH HHS K23 NS080912NINDS NIH HHS P50 NS053488
6 · The paper itself

Abstract

Sleep disorders are among the most common non-motor manifestations in Parkinson's disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005 to 2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. We discuss the epidemiology, etiology, clinical implications, associated features, evaluation measures, and management of these disorders. The influence on sleep of medications used in the treatment of motor and non-motor symptoms of PD is detailed. Additionally, we suggest areas in need of further research.

Indexed as

HumansParkinson DiseaseQuality of LifeSleep Wake DisordersCircadian rhythm disordersExcessive daytime sleepinessInsomniaParkinson's diseasePeriodic limb movementsREM sleep behavior disorderRestless legs syndromeSleep and neurodegenerationSleep disordered breathing

Identifiers

PMID27863901
PMCPMC5332351
OpenAlexW2513283541

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.