Evidence map›Paper›PMID 27863706›Full record

SynthesisSeminars in perinatology2016

Advanced neuroimaging and its role in predicting neurodevelopmental outcomes in very preterm infants.

Nehal A Parikh

Registry-linked trialOpen access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Seminars in perinatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03345069 (Early Prediction of Cognitive and Motor Deficits Using Advanced MRI in Very Preterm Infants), which is not on this map. Cited by 57 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 3 pooled it
11.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03345069 active not recruitingnot on this map

Early Prediction of Cognitive and Motor Deficits Using Advanced MRI in Very Preterm Infants

TypeobservationalSponsorChildren's Hospital Medical Center, CincinnatiRan2016 to 2027Enrolled393ConditionsPremature Infant
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
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  3. MRI-based brain volumes of preterm infants at term: a systematic review and meta-analysis.Archives of disease in childhood. Fetal and neonatal edition · 2022
    Pooled it
  4. Music Therapy Is Effective during Sleep in Preterm Infants.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Nehal A ParikhPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH. Electronic address: nehal.parikh@cchmc.org.
University of Cincinnati Medical Center · US

Funding

A New Model to Identify Preterm Neonates at High-Risk for Cognitive Impairments and School ReadinessR01NS094200 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI NEHAL A. PARIKH · 2016 to 2026
$6.7M
NINDS NIH HHS R01 NS094200
6 · The paper itself

Abstract

Up to 35% of very preterm infants survive with neurodevelopmental impairments (NDI) such as cognitive deficits, cerebral palsy, and attention deficit disorder. Advanced MRI quantitative tools such as brain morphometry, diffusion MRI, magnetic resonance spectroscopy, and functional MRI at term-equivalent age are ideally suited to improve current efforts to predict later development of disabilities. This would facilitate application of targeted early intervention therapies during the first few years of life when neuroplasticity is optimal. A systematic search and review identified 47 published studies of advanced MRI to predict NDI. Diffusion MRI and morphometry studies were the most commonly studied modalities. Despite several limitations, studies clearly showed that brain structural and metabolite biomarkers are promising independent predictors of NDI. Large representative multicenter studies are needed to validate these studies.

Indexed as

Infant, Extremely PrematureMagnetic Resonance ImagingNeuroimagingBrainDevelopmental DisabilitiesFetal Organ MaturityHumansInfant, NewbornInfant, Premature, DiseasesInfant, Very Low Birth WeightIntensive Care, NeonatalPredictive Value of TestsBrain metabolitesCerebral palsyCognitive impairmentDiffusion MRIFunctional MRIInfantMagnetic resonance imaging (MRI)Magnetic resonance spectroscopyMicrostructureMorphometryNeurodevelopmental impairmentPremature

Identifiers

PMID27863706
PMCPMC5951398
OpenAlexW2552159460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.