Evidence map›Paper›PMID 27863461›Full record

ArticleBMC genomics2016

Pooled genome wide association detects association upstream of FCRL3 with Graves' disease.

Jwu Jin Khong, Kathryn P Burdon, Yi Lu, Kate Laurie, Lefta Leonardos, Paul N Baird, Srujana Sahebjada, John P Walsh, Adam Gajdatsy, Peter R Ebeling and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  7. Review
  8. Linkage Analysis of the Chromosome 5q31-33 Region Identifies JAKMIP2 as a Risk Factor for Graves' Disease in the Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 11 institutions in 2 countries.

Jwu Jin KhongMelbourne Medical School Western Campus, Department of Medicine, University of Melbourne, Sunshine Hospital, 176 Furlong Road, St Albans, VIC, 3021, Australia. jwujinkhong@gmail.com.ORCID 0000-0002-2660-4668
Kathryn P BurdonMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
Yi LuStatistical Genetics, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Herston, QLD, Australia.
Kate LaurieDepartment of Ophthalmology, Flinders University of South Australia, Bedford Park, South Australia, Australia.
Lefta LeonardosDepartment of Ophthalmology, Flinders University of South Australia, Bedford Park, South Australia, Australia.
Paul N BairdDepartment of Surgery, Centre for Eye Research Australia and Ophthalmology, University of Melbourne, East Melbourne, VIC, Australia.
Srujana SahebjadaDepartment of Surgery, Centre for Eye Research Australia and Ophthalmology, University of Melbourne, East Melbourne, VIC, Australia.
John P WalshDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Adam GajdatsyCentre for Ophthalmology and Visual Sciences, University of Western Australia, Western Australia, Australia.
Peter R EbelingDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.
Peter Shane HamblinMelbourne Medical School Western Campus, Department of Medicine, University of Melbourne, Sunshine Hospital, 176 Furlong Road, St Albans, VIC, 3021, Australia.
Rosemary WongDepartment of Endocrinology and Diabetes, Western Health, St Albans, VIC, Australia.
Simon P ForehanDepartment of Diabetes and Endocrinology, Royal Melbourne Hospital, Parkville, VIC, Australia.
Spiros FourlanosDepartment of Diabetes and Endocrinology, Royal Melbourne Hospital, Parkville, VIC, Australia.
Anthony P RobertsDepartment of Endocrinology, The Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Matthew DoogueDepartment of Medicine, University of Otago, Christchurch, New Zealand.
Dinesh SelvaSouth Australian Institute of Ophthalmology, University of Adelaide, South Australia, Australia.
Grant W MontgomeryMolecular Epidemiology, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Herston, QLD, Australia.
Stuart MacgregorStatistical Genetics, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Herston, QLD, Australia.
Jamie E CraigDepartment of Ophthalmology, Flinders University of South Australia, Bedford Park, South Australia, Australia.
The University of Melbourne · AUFlinders University · AUQIMR Berghofer Medical Research Institute · AUThe Royal Melbourne Hospital · AUThe University of Western Australia · AUMonash University · AURoyal Adelaide Hospital · AUThe University of Adelaide · AUUniversity of Otago · NZUniversity of Tasmania · AUWestern Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGraves' disease is an autoimmune thyroid disease of complex inheritance. Multiple genetic susceptibility loci are thought to be involved in Graves' disease and it is therefore likely that these can be identified by genome wide association studies. This study aimed to determine if a genome wide association study, using a pooling methodology, could detect genomic loci associated with Graves' disease.

resultsNineteen of the top ranking single nucleotide polymorphisms including HLA-DQA1 and C6orf10, were clustered within the Major Histo-compatibility Complex region on chromosome 6p21, with rs1613056 reaching genome wide significance (p = 5 × 10

conclusionsPooled genome wide association study identified a genetic variant upstream of FCRL3 as a susceptibility locus for Graves' disease in addition to those identified in the Major Histo-compatibility Complex. A second locus downstream of DPYSL2 is potentially a novel genetic variant in Graves' disease that requires further confirmation.

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyAdultAgedAged, 80 and overCase-Control StudiesFemaleGenetic LociGenotypeGraves DiseaseHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideReceptors, ImmunologicFCRL3 protein, humanReceptors, ImmunologicGenome-wide association studyGraves’ diseasePooled blood

Identifiers

PMID27863461
PMCPMC5116198
OpenAlexW2556212556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.