Evidence map›Paper›PMID 27863410›Full record

ArticleOncotarget2016

Elevated expression of STIM1 is involved in lung tumorigenesis.

Yadong Wang, Haiyu Wang, Li Li, Jiangmin Li, Teng Pan, Ding Zhang, Haiyan Yang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Overview of CaExploration of targeted anti-tumor therapy · 2021
    Review
  2. Calcium Permeable Channels in Cancer Hallmarks.Frontiers in pharmacology · 2020
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yadong WangDepartment of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China.
Haiyu WangDepartment of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China.
Li LiDepartment of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China.
Jiangmin LiDepartment of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China.
Teng PanDepartment of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Ding ZhangDepartment of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China.
Haiyan YangDepartment of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Henan Provincial Center for Disease Control and Prevention · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to address the potential role of STIM1 (stromal interaction molecule 1) in lung tumorigenesis. Colony formation in soft agar assay and tumorigenicity in nude mice assay were conducted. Western blot, immunohistochemistry and quantitative real-time polymerase chain reaction were used to measure the STIM1 expression. The distribution of cell cycle was detected by flow cytometry assay. Our results showed that the expression of STIM1 mRNA was significantly higher in human lung tumors than that in adjacent non-neoplastic lung tissues. Significantly increased expression of STIM1 mRNA and protein was observed in 16HBE-benzo(a)pyrene (BaP) cells and in BaP-treated mice lung tissues compared with 16HBE-control cells and the control group, respectively. Silencing STIM1 inhibited the proliferation and colony formation of A549 cells in in vitro experiments, attenuated the growth of tumor xenografts of A549 cells in in vivo experiments and induced the arrest of cell cycle in the G1 phase. The markedly decreased expression of cyclin D1 protein was observed in A549-shRNA-STIM1 cells as compared to A549-shRNA-control cells. The markedly increased expression of p21 protein was observed in A549-shRNA-STIM1 cells as compared to A549-shRNA-control cells. The expression levels of β-catenin and TGIF proteins were lower in A549-shRNA-STIM1 cells than those in A549-shRNA-control cells. In conclusion, this study indicated that the elevated expression of STIM1 might be involved in lung tumorigenesis.

Indexed as

Adaptor Proteins, Vesicular TransportAnimalsBenzo(a)pyrenebeta CateninCarcinogenesisCell Line, TumorFemaleG1 Phase Cell Cycle CheckpointsHumansLung NeoplasmsMiceMice, Inbred BALB CNeoplasm ProteinsStromal Interaction Molecule 1Adaptor Proteins, Vesicular TransportBenzo(a)pyrenebeta CateninCTNNB1 protein, humanNeoplasm ProteinsSTIM1 protein, humanStromal Interaction Molecule 1TICAM1 protein, humanA549 cellcell cyclelung cancerSTIM1tumorigenicity

Identifiers

PMID27863410
PMCPMC5349937
OpenAlexW2552698602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.