Evidence map›Paper›PMID 27863333›Full record

Trial reportCytokine2017

Serum biomarkers of inflammation and muscle strength among women with systemic lupus erythematosus.

James S Andrews, Laura Trupin, Catherine L Hough, David I Daikh, Edward H Yelin, Patricia P Katz

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cytokine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The handgrip strength and risk of depressive symptoms: a meta-analysis of prospective cohort studies.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

James S AndrewsDepartment of Medicine, University of Washington, Seattle, USA. Electronic address: jsa1@uw.edu.
Laura TrupinDepartment of Medicine, University of California San Francisco, San Francisco, USA.
Catherine L HoughDepartment of Medicine, University of Washington, Seattle, USA.
David I DaikhDepartment of Medicine, University of California San Francisco, San Francisco, USA; Department of Medicine, San Francisco VA Medical Center, San Francisco, USA.
Edward H YelinDepartment of Medicine, University of California San Francisco, San Francisco, USA.
Patricia P KatzDepartment of Medicine, University of California San Francisco, San Francisco, USA.

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
The Interplay of Sociodemographic and Genetic Factors in SLE Health DisparitiesP60AR053308 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATZ, PATRICIA P · 2006 to 2016
$11.8M
NCRR NIH HHS KL2 RR024130NCRR NIH HHS UL1 RR024131NIAMS NIH HHS P60 AR053308
6 · The paper itself

Abstract

objectivesMuscle strength is an important determinant of physical function in women with systemic lupus erythematosus (SLE). Serum biomarkers of inflammation, including interleukin-6 (IL-6) and C-Reactive Protein (CRP), are associated with differences in muscle strength among individuals without rheumatologic disease. We examined whether serum levels of IL-6 and CRP are associated with upper and lower extremity muscle strength among adult women with SLE.

methodsOne hundred thirty-six women with SLE participated in this cross-sectional study. High-sensitivity CRP was analyzed by nephelometry. IL-6 serum levels were analyzed by high sensitivity enzyme-linked immunosorbent assay. Upper and lower extremity muscle strength were assessed by grip strength and peak torque of knee extension and flexion, respectively. Regression analyses modeled associations of CRP and IL-6 with upper and lower extremity muscle strength controlling for age, SLE duration, physical activity, prednisone use, BMI, plaquenil use, and pain.

resultsHigher serum levels of IL-6 and CRP were associated with significantly weaker upper and lower extremity muscle strength even when controlling for covariates.

conclusionsIncreased serum IL-6 and CRP are associated with clinically significant differences in upper and lower extremity muscle strength and may be useful in identifying those at risk for weakness and decreased physical function.

Indexed as

Muscle StrengthAdultBiomarkersC-Reactive ProteinFemaleHumansInflammation MediatorsInterleukin-6Lupus Erythematosus, SystemicMiddle AgedPrednisoloneBiomarkersC-Reactive ProteinIL6 protein, humanInflammation MediatorsInterleukin-6PrednisoloneCytokinesInflammationOutcomes researchSystemic lupus erythematosus

Identifiers

PMID27863333
PMCPMC5415383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.