Evidence map›Paper›PMID 27863314›Full record

Trial reportPsychiatry research2017

Cognitive remediation for adults with schizophrenia: Does age matter?

Silvia Corbera, Bruce E Wexler, Ania Poltorak, Warren R Thime, Matthew M Kurtz

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychiatry research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Community Rehabilitation for Youth with Psychosis Spectrum Disorders.Child and adolescent psychiatric clinics of North America · 2020
    Review
  19. Cognitive remediation in schizophrenia: the earlier the better?Epidemiology and psychiatric sciences · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Silvia CorberaSchizophrenia Rehabilitation Program, Institute of Living, Hartford, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Central Connecticut State University, New Britain, CT, USA.
Bruce E WexlerDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Ania PoltorakOlin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA; University of Saint Joseph,West Hartford, CT, USA.
Warren R ThimeSchizophrenia Rehabilitation Program, Institute of Living, Hartford, CT, USA.
Matthew M KurtzSchizophrenia Rehabilitation Program, Institute of Living, Hartford, CT, USA; Department of Psychology and Program in Neuroscience and Behavior, Wesleyan University, Middletown, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA. Electronic address: mkurtz@wesleyan.edu.
Hartford Financial Services (United States)Institute for Community Living · USUniversity of Saint Joseph · USYale University · US

Funding

Neurocognitive Rehabilitation for SchizophreniaK08MH069888 · NIMH · WESLEYAN UNIVERSITY · PI KURTZ, MATTHEW M · 2005 to 2009
$749k
NIMH NIH HHS K08 MH069888
6 · The paper itself

Abstract

Cognitive remediation (CR), a novel behavioral intervention designed to improve cognitive deficits through repeated task practice and/or strategy acquisition has gained increasing empirical support in people with schizophrenia, but substantial individual differences in treatment response remain (Wykes et al., 2011). The role of age on response to CR in schizophrenia remains understudied. We evaluated the role of three age ranges in treatment response to CR relative to a closely-matched computer skills control intervention in a blinded, randomized control trial (RCT) with 112 adults with schizophrenia divided into three groups: an early-stage group (ES; 25 years or younger, mean=3.4 years of illness; n=45), an early-chronic group (EC; 26-39, mean=7.6 years of illness; n=31) and a late-chronic group (LC; 40 and over, mean=18.2 years of illness; n=36). With respect to cognitive outcomes, early-stage and early-chronic individuals with schizophrenia showed greater improvement in response to CR on a working memory measure at a trend level, relative to late-chronic clients. These findings were confirmed in analyses of a subsample of clients who received an adequate dose of treatment. These findings emphasize the need for adaptations of currently-existing CR programs to more effectively address the needs of older client populations.

Indexed as

Age FactorsSchizophrenic PsychologyAdultCognition DisordersCognitive RemediationFemaleHumansMaleMemory, Short-TermSchizophreniaTreatment OutcomeYoung AdultAgeCognitive remediationEarly psychosisSchizophreniaWorking memory

Identifiers

PMID27863314
PMCPMC5248553
OpenAlexW2554200137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.