ArticleCell2016
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.
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Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 408 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
408citing papers in PubMed, 8 pooled it
36.6field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
408 citing papers in PubMed, 8 syntheses or guidelines pooled it, 771 citations in OpenAlex.
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- A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes.Genome medicine · 2023Pooled it
- Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data.Genome biology · 2023Pooled it
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- Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.Nature genetics · 2022Pooled it
- Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application.Molecular neurodegeneration · 2022Pooled it
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348 more citing papers are in PubMed but not listed here.
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Authors and funding
76 authors at 20 institutions in 7 countries.
Lu ChenDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK.
Bing GeHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada.
Francesco Paolo CasaleEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Louella VasquezDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Tony KwanHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada.
Diego Garrido-MartínBioinformatics and Genomics, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Carrer del Dr. Aiguader, 88, Barcelona 8003, Spain; Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Plaça de la Mercè, 10- 12, Barcelona 8002, Spain.
Stephen WattDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Ying YanDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Kousik KunduDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK.
Simone EckerStructural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernandez Almagro, 3, Madrid 28029, Spain; UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.
Avik DattaVertebrate Genomics, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
David RichardsonVertebrate Genomics, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Frances BurdenDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK.
Daniel MeadDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Alice L MannDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Jose Maria FernandezStructural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernandez Almagro, 3, Madrid 28029, Spain.
Sophia RowlstonDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK.
Steven P WilderGenome Analysis, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Samantha FarrowDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK.
Xiaojian ShaoHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada.
John J LambourneHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK.
Adriana RedensekHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada.
Cornelis A AlbersHuman Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, P.O. Box 9101, Nijmegen 6500 HB, the Netherlands; Molecular Developmental Biology, Radboud Institute for Life Sciences, Radboud University, P.O. Box 9101, Nijmegen 6500 HB, the Netherlands.
Vyacheslav AmstislavskiyDepartment of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 63/73, Berlin 14195, Germany.
Sofie AshfordDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK.
Kim BerentsenDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen 6525GA, the Netherlands.
Lorenzo BombaDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Guillaume BourqueHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada.
David BujoldHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada.
Stephan BuscheHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada.
Maxime CaronHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada.
Shu-Huang ChenHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada.
Warren CheungHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada.
Oliver DelaneauGenetic Medicine and Development, University of Geneva Medical School-CMU, 1 Rue Michel-Servet, Geneva 1211, Switzerland.
Emmanouil T DermitzakisGenetic Medicine and Development, University of Geneva Medical School-CMU, 1 Rue Michel-Servet, Geneva 1211, Switzerland.
Heather EldingDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Irina ColgiuHuman Genetics Informatics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Frederik O BaggerDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK.
Paul FlicekVertebrate Genomics, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Ehsan HabibiDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen 6525GA, the Netherlands.
Valentina IotchkovaDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Eva Janssen-MegensDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen 6525GA, the Netherlands.
Bowon KimDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen 6525GA, the Netherlands.
Hans LehrachDepartment of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 63/73, Berlin 14195, Germany.
Ernesto LowyVertebrate Genomics, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Amit MandoliDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen 6525GA, the Netherlands.
Filomena MatareseDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen 6525GA, the Netherlands.
Matthew T MauranoInstitute for Systems Genetics, New York University Langone Medical Center, ACLS West, Room 511, 430 East 29(th) Street, New York, NY 10016, USA.
John A MorrisHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada.
Vera PancaldiStructural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernandez Almagro, 3, Madrid 28029, Spain.
Farzin PourfarzadBlood Cell Research, Sanquin Research and Landsteiner Laboratory, Plesmanlaan 125, Amsterdam 1066CX, the Netherlands.
Karola RehnstromDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK.
Augusto RendonDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; Bioinformatics, Genomics England, Charterhouse Square, London EC1M 6BQ, UK.
Thomas RischDepartment of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 63/73, Berlin 14195, Germany.
Nilofar SharifiDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen 6525GA, the Netherlands.
Marie-Michelle SimonHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada.
Marc SultanDepartment of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 63/73, Berlin 14195, Germany.
Alfonso ValenciaStructural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernandez Almagro, 3, Madrid 28029, Spain.
Klaudia WalterDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Shuang-Yin WangDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen 6525GA, the Netherlands.
Mattia FrontiniDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Stylianos E AntonarakisGenetic Medicine and Development, University of Geneva Medical School-CMU, 1 Rue Michel-Servet, Geneva 1211, Switzerland.
Laura ClarkeVertebrate Genomics, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Marie-Laure YaspoDepartment of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 63/73, Berlin 14195, Germany.
Stephan BeckUCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.
Roderic GuigoBioinformatics and Genomics, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Carrer del Dr. Aiguader, 88, Barcelona 8003, Spain; Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Plaça de la Mercè, 10- 12, Barcelona 8002, Spain; Computational Genomics, Institut Hospital del Mar d'Investigacions Mediques (IMIM), Carrer del Dr. Aiguader, 88, Barcelona 8003, Spain.
Daniel RicoStructural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernandez Almagro, 3, Madrid 28029, Spain; Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Joost H A MartensDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen 6525GA, the Netherlands.
Willem H OuwehandDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, Strangeways Research Laboratory, University of Cambridge, Wort's Causeway, Cambridge CB1 8RN, UK.
Taco W KuijpersDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Plesmanlaan 125, Amsterdam 1066CX, the Netherlands; Emma Children's Hospital, Academic Medical Center (AMC), University of Amsterdam, Location H7-230, Meibergdreef 9, Amsterdam 1105AZ, the Netherlands.
Dirk S PaulUCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Wort's Causeway, Cambridge CB1 8RN, UK.
Hendrik G StunnenbergDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen 6525GA, the Netherlands.
Oliver StegleEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Kate DownesDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK.
Tomi PastinenHuman Genetics, McGill University, 740 Dr. Penfield, Montreal, QC H3A 0G1, Canada. Electronic address: tomi.pastinen@mcgill.ca.
Nicole SoranzoDepartment of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, Strangeways Research Laboratory, University of Cambridge, Wort's Causeway, Cambridge CB1 8RN, UK. Electronic address: ns6@sanger.ac.uk.
McGill University · CARadboud University Nijmegen · NLWellcome Sanger Institute · GBUniversity of Cambridge · GBMax Planck Institute for Molecular Genetics · DEEuropean Bioinformatics Institute · GBNational Health Service · GBSpanish National Cancer Research Centre · ESWellcome Trust · GBUniversity of Geneva · CHGenomics (United Kingdom) · GBUniversity College London · GBAddenbrooke's Hospital · GBCentre for Genomic Regulation · ESGenomics England · GBHospital del Mar Research Institute · ESNewcastle University · GBNYU Langone Health · USRadboud Institute for Molecular Life Sciences · NLSanquin · NL
Funding
British Heart Foundation RG/09/012/28096Department of Health RP-PG-0310-1002Medical Research Council G0800270Wellcome Trust
Abstract
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease phenotypes is a major challenge in human genetics and medicine. We carried out high-resolution genetic, epigenetic, and transcriptomic profiling in three major human immune cell types (CD14
Indexed as
EpigenomicsTranscription, GeneticAdultAgedAlternative SplicingFemaleGenetic Predisposition to DiseaseHematopoietic Stem CellsHistone CodeHumansImmune System DiseasesMaleMiddle AgedMonocytesNeutrophilsQuantitative Trait Lociallele specificDNA methylationEWAShistone modificationimmunemonocyteneutrophilQTLt-celltransription
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