Evidence map›Paper›PMID 27863227›Full record

ArticleMolecular cell2016

Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca

Pulak Kar, Gary R Mirams, Helen C Christian, Anant B Parekh

Open access · hybridAbstract read
In one paragraph

Article in Molecular cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Gene expression regulation by CaCellular & molecular biology letters · 2026
    Pooled it
  2. Article
  3. Temporal immunomodulation of CD4Science advances · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Activation of nuclear CaCell reports · 2026
    Article
  8. Review
  9. Article
  10. Analysis of Store-Operated CaMethods in molecular biology (Clifton, N.J.) · 2025
    Article
  11. House dust mite allergens, store-operated CaThe Journal of physiology · 2024
    Review
  12. Article
  13. Multifaceted control of T cell differentiation by STIM1.Trends in biochemical sciences · 2023
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Inositol 1,4,5-trisphosphate receptors in cardiomyocyte physiology and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  19. Article
  20. Modern physiology vindicates Darwin's dream.Experimental physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Pulak KarDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
Gary R MiramsComputational Biology, Department of Computer Science, University of Oxford, Parks Road, Oxford, OX1 3QD, UK.
Helen C ChristianDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
Anant B ParekhDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK. Electronic address: anant.parekh@dpag.ox.ac.uk.
University of Oxford · GB

Funding

Medical Research Council MR/L01047X/1Wellcome TrustWellcome Trust 101222/Z/13/Z
6 · The paper itself

Abstract

Excitation-transcription coupling, linking stimulation at the cell surface to changes in nuclear gene expression, is conserved throughout eukaryotes. How closely related coexpressed transcription factors are differentially activated remains unclear. Here, we show that two Ca

Indexed as

Calcium SignalingAnimalsBasophilsBronchiCalciumCell LineCell Line, TumorEnzyme InhibitorsGene Expression RegulationGreen Fluorescent ProteinsHEK293 CellsHumansInositol 1,4,5-Trisphosphate ReceptorsInositol PhosphatesLeukotriene C4NFATC Transcription FactorsCalciumEnzyme InhibitorsGreen Fluorescent Proteinsinositol 1,2,3-trisphosphateInositol 1,4,5-Trisphosphate ReceptorsInositol PhosphatesLeukotriene C4NFATC2 protein, humanNFATC3 protein, humanNFATC Transcription FactorsRecombinant Fusion ProteinsThapsigargin

Identifiers

PMID27863227
PMCPMC5128683
OpenAlexW2549673184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.