ArticleAngewandte Chemie (International ed. in English)2016
Protein-Sized Bright Fluorogenic Nanoparticles Based on Cross-Linked Calixarene Micelles with Cyanine Corona.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The Rise and Promise of Macrocyclic Hosts in Biomedicine.ACS central science · 2025Review
- Light-Harvesting Nanomaterials Based on Dyes for Energy Transfer and Amplified Biosensing.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Recent Advances in Calixarene-Based Fluorescent Sensors for Biological Applications.Sensors (Basel, Switzerland) · 2024Review
- Supramolecular Nano-Tracker for Real-Time Tracking of Drug Release and Efficient Combination Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- pH-Induced Transition Between Single-Chain Macrocyclic Amphiphile and [Frontiers in chemistry · 2019Article
- Fluorescence Resonance Energy Transfer Systems in Supramolecular Macrocyclic Chemistry.Molecules (Basel, Switzerland) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The key challenge in the field of fluorescent nanoparticles (NPs) for biological applications is to achieve superior brightness for sizes equivalent to single proteins (3-7 nm). We propose a concept of shell-cross-linked fluorescent micelles, in which PEGylated cyanine 3 and 5 bis-azides form a covalently attached corona on micelles of amphiphilic calixarene bearing four alkyne groups. The fluorescence quantum yield of the obtained monodisperse NPs, with a size of 7 nm, is a function of viscosity and reached up to 15 % in glycerol. In the on-state they are circa 2-fold brighter than quantum dots (QD-585), which makes them the smallest PEGylated organic NPs of this high brightness. FRET between cyanine 3 and 5 cross-linkers at the surface of NPs suggests their integrity in physiological media, organic solvents, and living cells, in which the NPs rapidly internalize, showing excellent imaging contrast. Calixarene micelles with a cyanine corona constitute a new platform for the development of protein-sized ultrabright fluorescent NPs.
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Registered trials
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