ArticleDiseases of the esophagus : official journal of the International Society for Diseases of the Esophagus2017
An age-period-cohort analysis of obesity and incident esophageal adenocarcinoma among white males.
Article in Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review on the association of month and season of birth with future anthropometric measures.Pediatric research · 2021Pooled it
- Economic Burden of Obesity: A Systematic Literature Review.International journal of environmental research and public health · 2017Pooled it
- Multi-omic characterization of early-onset esophagogastric cancer.NPJ precision oncology · 2025Article
- Exploring Disparities for Obesity in Korea Using Hierarchical Age-Period-Cohort Analysis With Cross-Classified Random Effect Models.Journal of Korean medical science · 2024Article
- Treatment and survival analysis for 40-year SEER data on upper esophageal cancer.Frontiers in medicine · 2023Article
- Comprehensive analysis of the relationship between cuproptosis-related genes and esophageal cancer prognosis.World journal of clinical cases · 2022Article
- Article
- Sex Differences in the Incidence of Obesity-Related Gastrointestinal Cancer.International journal of molecular sciences · 2021Review
- Epidemiology and Outcomes of Young-Onset Esophageal Adenocarcinoma: An Analysis from a Population-Based Database.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Trends in the incidence and survival of patients with esophageal cancer: A SEER database analysis.Thoracic cancer · 2020Article
- Nomogram predicting cancer-specific mortality in patients with esophageal adenocarcinoma: a competing risk analysis.Journal of thoracic disease · 2019Article
- Clinical characteristics of young patients with early Barrett's neoplasia.World journal of gastroenterology · 2019Article
- Use of age-period-cohort analysis in cancer epidemiology research.Current epidemiology reports · 2018Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades. Increases in incidence have been attributed to changes in the prevalence of risk factors for EAC; however, the extent to which these changes explain increases in EAC incidence has not been studied in detail. We used age-period-cohort analysis to estimate changes in the incidence of EAC among white males by age, time period, and birth cohort. Incidence rates per 100,000 individuals were analyzed from 1973 to 2012. Hierarchical Poisson models were used to estimate age, period, and cohort effects, whereby age-specific incidence rates were nested within periods and cohorts. The prevalence of obesity for each time period and birth cohort was included in the model as a fixed-effect. Incidence increased with advancing age (β = 0.12, P < 0.01). There were significant period and birth cohort effects, although the period effect was much larger than the cohort effect. The period effect decreased dramatically when obesity was included as a fixed effect, while the small cohort effect remained unchanged. Results suggest much of the increase in the incidence of EAC can be attributed to a period effect, which may be due to changes in the prevalence of obesity over time.
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