ArticleHuman brain mapping2017
Serotonergic modulation of orbitofrontal activity and its relevance for decision making and impulsivity.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Spatio-temporal differences in EEG dynamics during decision-making between online poker players with moderate-risk and high-risk gambling activity.Scientific reports · 2026Article
- Sound intensity-dependent cortical activation: implications of the electrical and vascular activity on auditory intensity.Cognitive neurodynamics · 2025Article
- Review
- Spatio-temporal EEG dynamics during decision-making in online poker players with problem gambling.Journal of behavioral addictions · 2024Article
- The Loudness Dependence of Auditory Evoked Potentials is associated with the Symptom Severity and Treatment in Boys with Attention Deficit Hyperactivity Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Article
- P300 and delay-discounting in obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2022Article
- Differential spatial patterns of structural connectivity of amygdala nuclei with orbitofrontal cortex.Human brain mapping · 2021Article
- Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Comparison of Behavioral Changes and Brain Activity between Adolescents with Internet Gaming Disorder and Student Pro-Gamers.International journal of environmental research and public health · 2020Article
- Reduced orbitofrontal-thalamic functional connectivity related to suicidal ideation in patients with major depressive disorder.Scientific reports · 2017Article
- An adaptive, individualized fMRI delay discounting procedure to increase flexibility and optimize scanner time.NeuroImage · 2017Article
- A meta-analysis of neural systems underlying delay discounting: Implications for transdiagnostic research.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe orbitofrontal cortex seems to play a crucial role in reward-guided learning and decision making, especially for impulsive choice procedures including delayed reward discounting. The central serotonergic system is closely involved in the regulation of impulsivity, but how the serotonergic firing rate and release, best investigated by the loudness dependence of auditory evoked potentials (LDAEP), interact with orbitofrontal activity is still unknown.
methodsTwenty healthy volunteers (11 males, 9 females, 31.3 ± 10.6 years old) were studied in a 3T MRI scanner (Philips, Hamburg, Germany) during a delay discounting task, after their LDAEP was recorded using a 32 electrodes EEG machine (Brain Products, Munich, Germany).
resultsSignificant positive correlations were only found between the LDAEP and the medial orbitofrontal part of the superior frontal gyrus (SFG/MO) [Δ immediate reward - delayed reward] for the right (r = 0.519; P = 0.019) and left side (r = 0.478; P = 0.033). This relationship was stronger for females compared with males. Orbitofrontal activity was also related to the Barratt Impulsivity Scale.
conclusionsThis study revealed that low serotonergic activity as measured by a strong LDAEP was related to a high fMRI signal intensity of SFG/MO during immediate reward behavior which is related to impulsivity. Since this relationship was only found for the infralimbic medial and not for the middle or lateral part of the orbitofrontal cortex, an exclusive projection tract of the serotonergic system to this cortical region can be assumed to regulate impulsive reward-orientated decision making. Hum Brain Mapp 38:1507-1517, 2017. © 2016 Wiley Periodicals, Inc.
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