ArticleMolecular ecology2017
Co-evolutionary dynamics between a defensive microbe and a pathogen driven by fluctuating selection.
Article in Molecular ecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Article
- Assessing the microbiota of the snail intermediate host of trematodes, Galba truncatula.Parasites & vectors · 2024Article
- Tolerance-conferring defensive symbionts and the evolution of parasite virulence.Evolution letters · 2023Article
- Host-Associated Rhizobial Fitness: Dependence on Nitrogen, Density, Community Complexity, and Legume Genotype.Applied and environmental microbiology · 2022Article
- Temporal changes in pathogen diversity in a perennial plant-pathogen-hyperparasite system.Molecular ecology · 2022Article
- Microbial evolution and transitions along the parasite-mutualist continuum.Nature reviews. Microbiology · 2021Review
- Genetic identity and genotype × genotype interactions between symbionts outweigh species level effects in an insect microbiome.The ISME journal · 2021Article
- Host genotype and genetic diversity shape the evolution of a novel bacterial infection.The ISME journal · 2021Article
- Host microbiota can facilitate pathogen infection.PLoS pathogens · 2021Review
- In Vivo Microbial Coevolution Favors Host Protection and Plastic Downregulation of Immunity.Molecular biology and evolution · 2021Article
- Association with a novel protective microbe facilitates host adaptation to a stressful environment.Evolution letters · 2021Article
- Ecological and evolutionary perspectives on tick-borne pathogen co-infections.Current research in parasitology & vector-borne diseases · 2021Review
- The hemolymph of Biomphalaria snail vectors of schistosomiasis supports a diverse microbiome.Environmental microbiology · 2020Article
- Microbiome-mediated plasticity directs host evolution along several distinct time scales.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Evolution and maintenance of microbe-mediated protection under occasional pathogen infection.Ecology and evolution · 2020Article
- An interaction between host and microbe genotypes determines colonization success of a key bumble bee gut microbiota member.Evolution; international journal of organic evolution · 2019Article
- Ecology and evolution of facilitation among symbionts.Nature communications · 2018Review
- Mutual fitness benefits arise during coevolution in a nematode-defensive microbe model.Evolution letters · 2018Article
- Back to the future in a petri dish: Origin and impact of resurrected microbes in natural populations.Evolutionary applications · 2018Review
- A Model for Evolutionary Ecology of Disease: The Case forJournal of nematology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbes that protect their hosts from pathogenic infection are widespread components of the microbiota of both plants and animals. It has been found that interactions between 'defensive' microbes and pathogens can be genotype-specific and even underlie the variation in host resistance to pathogenic infection. These observations suggest a dynamic co-evolutionary association between pathogens and defensive microbes, but direct evidence of co-evolution is lacking. We tested the hypothesis that defensive microbes and pathogens could co-evolve within host populations by co-passaging a microbe with host-defensive properties (Enterococcus faecalis) and a pathogen (Staphylococcus aureus) within Caenorhabditis elegans nematodes. Using both phenotypic and genomic analyses across evolutionary time, we found patterns of pathogen local adaptation and defensive microbe-pathogen co-evolution via fluctuating selection dynamics. Moreover, co-evolution with defensive microbes resulted in more rapid and divergent pathogen evolution compared to pathogens evolved independently in host populations. Taken together, our results indicate the potential for defensive microbes and pathogens to co-evolve, driving interaction specificity and pathogen evolutionary divergence in the absence of host evolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.