ArticleYeast (Chichester, England)2017
It's not all about us: evolution and maintenance of Cryptococcus virulence requires selection outside the human host.
Article in Yeast (Chichester, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Divergent paths:Current medical mycology · 2024Article
- The Cryptococcus gattii species complex: Unique pathogenic yeasts with understudied virulence mechanisms.PLoS neglected tropical diseases · 2022Review
- Melanin deposition in twoThe Journal of biological chemistry · 2020Article
- Environmental Factors That Contribute to the Maintenance ofMicroorganisms · 2020Review
- Article
- Small RNA AvrA Regulates IscR to Increase the Stress Tolerances in SmpB Deficiency ofFrontiers in cellular and infection microbiology · 2019Article
- Diverse Lineages ofGenetics · 2019Article
- Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators.PLoS pathogens · 2018Article
- N-acetylglucosamine affects Cryptococcus neoformans cell-wall composition and melanin architecture.Microbiology (Reading, England) · 2017Article
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Authors and funding
2 authors.
Funding
Abstract
Cryptococcus is predominantly an AIDS-related pathogen that causes significant morbidity and mortality in immunocompromised patients. Research studies have historically focused on understanding how the organism causes human disease through the use of in vivo and in vitro model systems to identify virulence factors. Cryptococcus is not an obligate pathogen, however, as human-human transmission is either absent or rare. Selection in the environment must thus be invoked to shape the evolution of this taxa, and directly influences genotypic and trait diversity. Importantly, the evolution and maintenance of pathogenicity must also stem directly from environmental selection. To that end, here we examine abiotic and biotic stresses in the environment, and discuss how they could shape the factors that are commonly identified as important virulence traits. We identify a number of important unanswered questions about Cryptococcus diversity and evolution that are critical for understanding this deadly pathogen, and discuss how implementation of modern sampling and genomic tools could be utilized to answer these questions. Copyright © 2016 John Wiley & Sons, Ltd.
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