ArticleActa paediatrica (Oslo, Norway : 1992)2017
The early postnatal nutritional intake of preterm infants affected neurodevelopmental outcomes differently in boys and girls at 24 months.
Article in Acta paediatrica (Oslo, Norway : 1992), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Neurodevelopmental Outcome in Very Preterm Infants Randomised to Receive Two Different Standardised, Concentrated Parenteral Nutrition Regimens.Nutrients · 2023Trial
- Impact of introducing a standardized nutrition protocol on very premature infants' growth and morbidity.PloS one · 2020Trial
- Sex-differences in Mothers' own milk and neurodevelopmental outcomes in preterm infants.Frontiers in pediatrics · 2025Article
- Effectiveness of the novel 3D PreemieScanner for preterm infants' growth monitoring confirmed in a simulated setting.Frontiers in medical technology · 2025Article
- Impact of sex, race, and social determinants of health on neonatal outcomes.Frontiers in pediatrics · 2024Review
- Article
- Sex differences in preterm nutrition and growth: the evidence from human milk associated studies.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Nonlinear relationship between early postnatal weight gain velocity and neurodevelopmental outcomes in very-low birth weight preterm infants: A secondary analysis based on a published prospective cohort study.Frontiers in pediatrics · 2022Article
- Length of Nutritional Transition Associates Negatively with Postnatal Growth in Very Low Birthweight Infants.Nutrients · 2021Article
- Association Between Early Amino Acid Intake and Full-Scale IQ at Age 5 Years Among Infants Born at Less Than 30 Weeks' Gestation.JAMA network open · 2021Article
- Do preterm girls need different nutrition to preterm boys? Sex-specific nutrition for the preterm infant.Pediatric research · 2021Review
- Calorie intake is associated with weight gain during transition phase of nutrition in female extremely low birth weight infants.Biology of sex differences · 2020Article
- Sex-specific relationships between early nutrition and neurodevelopment in preterm infants.Pediatric research · 2020Article
- The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review.Nutrients · 2019Review
- Male sex is an independent risk factor for poor neurodevelopmental outcome at 20 months' corrected age, in human milk-fed very preterm infants: a cohort study.Einstein (Sao Paulo, Brazil) · 2019Article
- Macronutrient variability in human milk from donors to a milk bank: Implications for feeding preterm infants.PloS one · 2019Observational
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study assessed whether increased amino acid and energy intake in preterm infants during the first week of life was associated with improved neurodevelopment at the corrected age (CA) of 24 months.
methodsWe evaluated preterm infants from two consecutive cohorts in 2004 (Cohort 1) and 2005 (Cohort 2) with different nutritional intakes in the Netherlands. Nutritional intake and growth were recorded until week 5 and after discharge. Neurodevelopment was determined using the Bayley Scales of Infant Development - Second Edition at a CA of 24 months.
resultsCompared to Cohort 1 (n = 56), Cohort 2 (n = 56) received higher nutritional intake during week 1 (p < 0.001). The weight gain in Cohort 2 was higher until week 5, especially among boys (p < 0.002). The mean Mental Developmental Index (MDI) scores did not differ, but Cohort 2 was associated with an increased chance of having an MDI ≥ 85, with an odds ratio of 6.4 and 95% confidence interval (CI) of 1.5-27.4, among all girls with a higher protein intake (5.3, 1.2-23.3). The Psychomotor Developmental Index increased with increasing nutritional intake, especially among boys (β-coefficient 3.1, 95% CI 0.2-6.0).
conclusionHigher nutritional intake was associated with different improvements in growth and neurodevelopment in boys and girls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.