ReviewHepatology (Baltimore, Md.)2017
Pediatric acute liver failure of undetermined cause: A research workshop.
Review in Hepatology (Baltimore, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Immune mechanisms and pathophysiology of T cell-mediated pediatric acute liver failure (TC-PALF).Hepatology communications · 2026Review
- Fulminant Hepatitis Due to Enterovirus E25 Systemic Infection in a Pediatric Patient.Pathogens (Basel, Switzerland) · 2026Article
- Acute severe cholestatic hepatitis and lymphopenia characterize pediatric hepatitis-associated aplastic anemia.Journal of pediatric gastroenterology and nutrition · 2026Article
- Effect of oral l-carnitine on hepatic function in pediatric patients under repair of congenital cardiac defect.Annals of medicine and surgery (2012) · 2025Article
- Acute Liver Failure with Determinate rather than Indeterminate Etiology Facilitates Therapy and May Avoid Liver Transplantation: A Critical Analysis.Journal of clinical and translational hepatology · 2025Review
- Systemic T-cell activation and IFN-γ activity in indeterminate severe hepatitis are reminiscent of hemophagocytic lymphohistiocytosis: Implications for T-cell- and IFN-γ-directed therapies.The Journal of allergy and clinical immunology · 2025Article
- Label-Free Proteomics of Severe Acute Hepatitis of Unknown Origin in Children by High-Resolution Mass Spectrometry.ACS omega · 2024Article
- Article
- Prognostic Markers in Pediatric Acute Liver Failure.GE Portuguese journal of gastroenterology · 2024Article
- Whole-exome sequencing for genetic diagnosis of idiopathic liver injury in children.Journal of cellular and molecular medicine · 2024Article
- Coronavirus HKU1 infection and development of pediatric acute liver failure with immune dysregulation phenotype.JPGN reports · 2024Article
- Liver injury in cynomolgus monkeys following intravenous and intrathecal scAAV9 gene therapy delivery.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Secondary hemophagocytic lymphohistiocytosis in children (Review).Experimental and therapeutic medicine · 2023Review
- Adenovirus is Not Detected in Liver Tissue From a Historical Multicenter Cohort of Children With Acute Liver Failure.Journal of pediatric gastroenterology and nutrition · 2023Article
- The Liver in Hemophagocytic Lymphohistiocytosis: Not an Innocent Bystander.Journal of pediatric gastroenterology and nutrition · 2023Review
- Pediatric Acute Liver Failure.Pediatric reports · 2023Article
- Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Covid-19 - Single-Center Experience.Indian pediatrics · 2023Article
- Identifying the Aetiology of Acute Liver Failure Is Crucial to Impact Positively on Outcome.Children (Basel, Switzerland) · 2023Article
- Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights.Clinical and experimental immunology · 2023Review
- Solved the enigma of pediatric severe acute hepatitis of unknown origin?Frontiers in cellular and infection microbiology · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Pediatric acute liver failure (PALF) is a potentially devastating condition that occurs in previously healthy children of all ages and frequently leads to a rapid clinical deterioration. An identified cause for liver injury is lacking in approximately 30% of cases. Children with undetermined diagnosis have lower spontaneous survival and higher rates of transplantation and death than other diagnostic groups. A single-day workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases brought together clinicians and basic scientists to integrate aligned research findings and develop a foundation for new mechanistic studies and future treatment trials. The clinical phenotype of indeterminate PALF shares important similarities to the hyperinflammatory state characteristic of hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS). A failure of cytotoxic T cells to limit or contract inflammatory responses may propagate injury and lead to a local and systemic milieu that does not support normal hepatic regeneration. Evidence was presented that bone marrow (BM)-derived Sinusoidal endothelial cell PROgenitor Cells (sprocs) play a vital role in hepatic regeneration. Overwhelming systemic inflammatory responses may suppress mobilization of BM sprocs and dampen hepatic recovery.
conclusionExperience gained through treatment trials of HLH and MAS in childhood may inform study design for therapy of PALF. Successful approaches to limiting neuroinflammation through reduction of systemic inflammation and standardized neuroprotection protocols that limit glial injury could significantly improve intact survival. Finally, given that PALF is a rare disease, investigative efforts must include broad multicenter collaboration and careful stewardship of biorepository specimens. (Hepatology 2017;65:1026-1037).
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