Evidence map›Paper›PMID 27861988›Full record

ReviewAllergy2017

Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria.

A P Kaplan, A M Giménez-Arnau, S S Saini

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03111628 (Role of Immunoglobulin E), which is not on this map. Cited by 108 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 2 pooled it
21.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03111628 phase4completednot on this map

Role of Immunoglobulin E (IgE) Bearing Cells in Chronic Idiopathic Urticaria

TypeinterventionalSponsorJohns Hopkins UniversityRan2017 to 2020Enrolled18ConditionsUrticaria ChronicArmsOmalizumab
3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 2 syntheses or guidelines pooled it, 277 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Response of FcεRI-bearing leucocytes to omalizumab in chronic spontaneous urticaria.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020
    Trial
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Targeting Mast Cells in Chronic Spontaneous Urticaria.Current allergy and asthma reports · 2026
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

A P KaplanDivision of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
A M Giménez-ArnauDepartment of Dermatology, Hospital del Mar, Institut Mar D'Investigacions Mediques, Universitat Autònoma, Barcelona, Spain.
S S SainiJohns Hopkins Asthma and Allergy Center, Baltimore, MD, USA.
Hospital del Mar Research Institute · ESJohns Hopkins University · USMedical University of South Carolina · US

Funding

Role of IgE Bearing Cells in Chronic Idiopathic UrticariaR01AI116658 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SAINI, SARBJIT SINGH · 2016 to 2018
$1.4M
NIAID NIH HHS R01 AI116658
6 · The paper itself

Abstract

The monoclonal anti-immunoglobulin E (IgE) antibody, omalizumab, was the first drug approved for use in patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) who remain symptomatic despite H

Indexed as

AgranulocytosisAnimalsAnti-Allergic AgentsAntibodies, Monoclonal, HumanizedAutoantibodiesBasophilsChronic DiseaseHumansImmunoglobulin EImmunoglobulin GMast CellsOmalizumabReceptors, IgETreatment OutcomeUrticariaAnti-Allergic AgentsAntibodies, Monoclonal, HumanizedAutoantibodiesImmunoglobulin EImmunoglobulin GOmalizumabReceptors, IgEchronic idiopathic urticariachronic spontaneous urticariaomalizumab

Identifiers

PMID27861988
PMCPMC5915348
OpenAlexW2556598798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.