Evidence map›Paper›PMID 27861975›Full record

ReviewPhotochemistry and photobiology2017

Convergence of The Nobel Fields of Telomere Biology and DNA Repair.

Elise Fouquerel, Patricia L Opresko

Abstract readReview
In one paragraph

Review in Photochemistry and photobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Somatic growth and telomere dynamics in vertebrates: relationships, mechanisms and consequences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elise FouquerelDepartment of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, University of Pittsburgh Cancer Institute Research Pavilion, University of Pittsburgh, Pittsburgh, PA.
Patricia L OpreskoDepartment of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, University of Pittsburgh Cancer Institute Research Pavilion, University of Pittsburgh, Pittsburgh, PA.ORCID 0000-0002-6470-2189

Funding

Mechanisms of Telomere Resistance to DNA Lesion RemovalR01ES022944 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OPRESKO, PATRICIA L · 2013 to 2017
$1.6M
ROS driven mitochondrial-telomere dysfunction during environmental stressR33ES025606 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OPRESKO, PATRICIA L, VAN HOUTEN, BENNETT · 2017 to 2019
$1.6M
GammaPNA Miniprobes for Telomere Analysis and RNA FISHR44GM108187 · NIGMS · TRUCODE GENE REPAIR, INC. · PI ARMITAGE, BRUCE A., OPRESKO, PATRICIA L · 2016 to 2018
$1.4M
GammaPNA Miniprobes for Telomere FISHR43GM108187 · NIGMS · PNA INNOVATIONS, INC. · PI ARMITAGE, BRUCE A., OPRESKO, PATRICIA L · 2013 to 2014
$541k
ROS driven mitochondrial-telomere dysfunction during environmental stressR21ES025606 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OPRESKO, PATRICIA L, VAN HOUTEN, BENNETT · 2015 to 2016
$414k
NIEHS NIH HHS R01 ES022944NIEHS NIH HHS R21 ES025606NIEHS NIH HHS R33 ES025606NIGMS NIH HHS R43 GM108187NIGMS NIH HHS R44 GM108187
6 · The paper itself

Abstract

The fields of telomere biology and DNA repair have enjoyed a great deal of cross-fertilization and convergence in recent years. Telomeres function at chromosome ends to prevent them from being falsely recognized as chromosome breaks by the DNA damage response and repair machineries. Conversely, both canonical and nonconical functions of numerous DNA repair proteins have been found to be critical for preserving telomere structure and function. In 2009, Elizabeth Blackburn, Carol Greider and Jack Szostak were awarded the Nobel prize in Physiology or Medicine for the discovery of telomeres and telomerase. Four years later, pioneers in the field of DNA repair, Aziz Sancar, Tomas Lindahl and Paul Modrich were recognized for their seminal contributions by being awarded the Nobel Prize in Chemistry. This review is part of a special issue meant to celebrate this amazing achievement, and will focus in particular on the convergence of nucleotide excision repair and telomere biology, and will discuss the profound implications for human health.

Indexed as

DNA RepairTelomereChromosome AberrationsDeoxyribodipyrimidine Photo-LyaseDNA DamageHumansNobel PrizePyrimidine DimersTelomeraseUltraviolet RaysDeoxyribodipyrimidine Photo-Lyasepyrimidine(6-4)pyrimidone photolyasePyrimidine DimersTelomerase

Identifiers

PMID27861975
PMCPMC5315637

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.