ArticleThe Journal of physiology2017
Sildenafil therapy for fetal cardiovascular dysfunction during hypoxic development: studies in the chick embryo.
Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 36 citations in OpenAlex.
- Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care.Physiological reviews · 2026Review
- Translatable in-vivo investigation of effects of progressive hypoxia in pregnancy on fetal cardiac structure and function in sheep.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- Antioxidants: powering the fight against fetal hypoxia.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- The Use of Antioxidants for Cardiovascular Protection in Fetal Growth Restriction: A Systematic Review.Antioxidants (Basel, Switzerland) · 2024Review
- Prenatal Sildenafil and Fetal-placental Programming in Human Pregnancies Complicated by Fetal Growth Restriction: A Retrospective Gene Expression Analysis.Journal of trial and error · 2023Article
- Molecular mechanisms underlying adverse effects of dexamethasone and betamethasone in the developing cardiovascular system.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Embryonic Hyperglycemia Disrupts Myocardial Growth, Morphological Development, and Cellular Organization: An In Vivo Experimental Study.Life (Basel, Switzerland) · 2023Article
- Breath of Life: Heart Disease Link to Developmental Hypoxia.Circulation · 2021Article
- Maternal sildenafil impairs the cardiovascular adaptations to chronic hypoxaemia in fetal sheep.The Journal of physiology · 2020Article
- Preeclampsia link to gestational hypoxia.Journal of developmental origins of health and disease · 2019Review
- Prenatal Sildenafil Therapy Improves Cardiovascular Function in Fetal Growth Restricted Offspring of Dahl Salt-Sensitive Rats.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Placental Adaptation to Early-Onset Hypoxic Pregnancy and Mitochondria-Targeted Antioxidant Therapy in a Rodent Model.The American journal of pathology · 2018Article
- The highs and lows of programmed cardiovascular disease by developmental hypoxia: studies in the chicken embryo.The Journal of physiology · 2018Review
- Acute hypoxia-reoxygenation and vascular oxygen sensing in the chicken embryo.Physiological reports · 2017Article
- The chicken or the egg? Sildenafil therapy for fetal cardiovascular dysfunction during hypoxic development: studies in the chick embryo.The Journal of physiology · 2017Article
- The Roles of Reactive Oxygen Species and Nitric Oxide in Perfluorooctanoic Acid-Induced Developmental Cardiotoxicity and l-Carnitine Mediated Protection.International journal of molecular sciences · 2017Article
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4 authors at 1 institution in 1 country.
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Abstract
key pointsCommon complications of pregnancy, such as chronic fetal hypoxia, trigger a fetal origin of cardiovascular dysfunction and programme cardiovascular disease in later life. Sildenafil treatment protects placental perfusion and fetal growth, but whether the effects of sildenafil transcend the placenta to affect the fetus is unknown. Using the chick embryo model, here we show that sildenafil treatment directly protects the fetal cardiovascular system in hypoxic development, and that the mechanisms of sildenafil protection include reduced oxidative stress and increased nitric oxide bioavailability; Sildenafil does not protect against fetal growth restriction in the chick embryo, supporting the idea that the protective effect of sildenafil on fetal growth reported in mammalian studies, including humans, is secondary to improved placental perfusion. Therefore, sildenafil may be a good candidate for human translational antioxidant therapy to protect the chronically hypoxic fetus in adverse pregnancy. ABSTRACT: There is a need for developing clinically translatable therapy for preventing fetal origins of cardiovascular disease in pregnancy complicated by chronic fetal hypoxia. Evidence shows that sildenafil protects placental perfusion and fetal growth. However, whether beneficial effects of sildenafil transcend onto the fetal heart and circulation in complicated development is unknown. We isolated the direct effects of sildenafil on the fetus using the chick embryo and hypothesised that sildenafil also protects fetal cardiovascular function in hypoxic development. Chick embryos (n = 11 per group) were incubated in normoxia or hypoxia (14% O
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